ID   UXAC_STAHJ              Reviewed;         467 AA.
AC   Q4L320;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=SH2648;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC1435;
RX   PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA   Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; AP006716; BAE05957.1; -; Genomic_DNA.
DR   RefSeq; WP_011276887.1; NC_007168.1.
DR   AlphaFoldDB; Q4L320; -.
DR   SMR; Q4L320; -.
DR   STRING; 279808.SH2648; -.
DR   EnsemblBacteria; BAE05957; BAE05957; SH2648.
DR   GeneID; 58061306; -.
DR   KEGG; sha:SH2648; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_9; -.
DR   OMA; TDHGHPT; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000000543; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..467
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000044779"
SQ   SEQUENCE   467 AA;  54328 MW;  D3DE78446DD3CE1A CRC64;
     MAFINEHFML NNETGKHLYH DFAKDMPIYD YHCHLDPKQI SDNVACDNIT DLWLSGDHYK
     WRAMRAQGIE EQYITGDAAP LDKFKKWTET LENSVGNPLY HWSQLELKMY FDIEDLLTSD
     NAEAIYHRAN DYLKQHHTTT QSLITDSNVN LICTTDNPTD DLNYHDAIKA KDGFNTTVLP
     AFRPDDVFKV GDPAFTDLLQ KLENLTHPIT TPSDFIEALY KRIQYFHDKG GRLADHGLEE
     MHFEAYTDQA IQDIFKKALN HADISTYERF QFQSYMLNEL SKAYYERGWV MQIHFGAIRN
     NNTKMFEKVG KDAGFDSIRD QDNLAYHLNA TLDMMEQEGH LPKTILYNLN PIYNDIVGST
     IANFQTEPGI KSKVQHGAGW WFNDTKRGML RQMSSLADQG LLMHFVGMLT DSRSFISYSR
     HDYFRRILSS FIGDLVEKGE IPNDDQLLKR MIENICYNNA YNYFKLI