ID   UXAC_STRA3              Reviewed;         466 AA.
AC   Q8E6A3;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=gbs0674;
OS   Streptococcus agalactiae serotype III (strain NEM316).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=211110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEM316;
RX   PubMed=12354221; DOI=10.1046/j.1365-2958.2002.03126.x;
RA   Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T.,
RA   Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.;
RT   "Genome sequence of Streptococcus agalactiae, a pathogen causing invasive
RT   neonatal disease.";
RL   Mol. Microbiol. 45:1499-1513(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; AL766846; CAD46318.1; -; Genomic_DNA.
DR   RefSeq; WP_000143785.1; NC_004368.1.
DR   AlphaFoldDB; Q8E6A3; -.
DR   SMR; Q8E6A3; -.
DR   STRING; 211110.gbs0674; -.
DR   EnsemblBacteria; CAD46318; CAD46318; CAD46318.
DR   KEGG; san:gbs0674; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_9; -.
DR   OMA; TDHGHPT; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000000823; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..466
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172787"
SQ   SEQUENCE   466 AA;  53878 MW;  ECF8D94DE2528100 CRC64;
     MTFNTETFML KNQAAIQLYE EVKRQPIFDY HCHLDPKDIF EDRIFDNIVD LWLGGDHYKW
     RLMRANGISE AEITGPASNL EKFKAFARTL ERAYGNPVYH WSAMELKNVF GVNEILTESN
     AEEIYHRLNH FLKEHKISPR RLIADSKVMF IGTTDYPLDT LKWHKKLAAD ESFKTVVAPT
     FRPDEAFIEH RHFVDFITKL GDITQKEITD FSTFIAAMEE RIAYFAQNGC RASDISFTEI
     VFEQTDELEL NDLFNKVCEG YIPNQSEISK WQTAVFMELC RLYKKYGFVT QVHFGALRNN
     HSTIFEKLGA DVGVDSLGDQ VALTVNMNRL LDSLVKKDSL PKMIWYNLNP AYNIAVANTL
     ANFQANELGV RSYLQFGAGW WFADTKLGMI SQMNALAEQG MLANFIGMLT DSRSFLSYQR
     HDYFRRILCT YLGEWIEEGE VPEDYQALGS MAKDIAYQNA VNYFKN