ID   UXAC_STREM              Reviewed;         465 AA.
AC   B4U237;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=Sez_0689;
OS   Streptococcus equi subsp. zooepidemicus (strain MGCS10565).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=552526;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGCS10565;
RX   PubMed=18716664; DOI=10.1371/journal.pone.0003026;
RA   Beres S.B., Sesso R., Pinto S.W.L., Hoe N.P., Porcella S.F., Deleo F.R.,
RA   Musser J.M.;
RT   "Genome sequence of a lancefield group C Streptococcus zooepidemicus strain
RT   causing epidemic nephritis: new information about an old disease.";
RL   PLoS ONE 3:E3026-E3026(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP001129; ACG62054.1; -; Genomic_DNA.
DR   RefSeq; WP_012515330.1; NC_011134.1.
DR   AlphaFoldDB; B4U237; -.
DR   SMR; B4U237; -.
DR   PRIDE; B4U237; -.
DR   EnsemblBacteria; ACG62054; ACG62054; Sez_0689.
DR   KEGG; sez:Sez_0689; -.
DR   HOGENOM; CLU_044465_1_0_9; -.
DR   OMA; TDHGHPT; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001873; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..465
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000131610"
SQ   SEQUENCE   465 AA;  53543 MW;  137991F9F6EB3796 CRC64;
     MAFNDDNFML KNEAAKRLYQ QIKDQPIFDY HCHLDPKEIF EDKVYDNIVD LWLGGDHYKW
     RLMRANGISE EEITGSASKL DKFKAFARTL QRSYGNPVYH WSVMELKNVF GVCELLTEDN
     AEEIYHRINA YLVEHQISPR KLIADSRVRF IGTTDHPLDD LAWHKRLTAD DTFETVVAPT
     FRPDEAFIEH QRFADFVARL AQATGRTITD FKSFIAAMEE RIAYFAENGC KASDISFTEI
     VFEAAEPEQL DRLMTRVLEG YQPQPLEIKQ WQTAVFAELC RLYKHYGFVT QVHFGALRNN
     HSAIFNKLGA DVGVDSLGDQ AALAINMNRL LDHLVQRDSL PKMIWYNLNP SYNITVPNTL
     ANFQANENGI AGYLQFGAGW WFADTKLGMI SQMNALAEQG LLANFVGMLT DSRSFLSYQR
     HDYFRRILST YLGEWIEEGE VPEDYQVLGS MAKDIAYNNA IQYFS