ID   UXAC_STRP7              Reviewed;         466 AA.
AC   C1CAV7;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675};
GN   OrderedLocusNames=SP70585_2238;
OS   Streptococcus pneumoniae (strain 70585).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=488221;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70585;
RX   PubMed=21034474; DOI=10.1186/gb-2010-11-10-r107;
RA   Donati C., Hiller N.L., Tettelin H., Muzzi A., Croucher N.J.,
RA   Angiuoli S.V., Oggioni M., Dunning Hotopp J.C., Hu F.Z., Riley D.R.,
RA   Covacci A., Mitchell T.J., Bentley S.D., Kilian M., Ehrlich G.D.,
RA   Rappuoli R., Moxon E.R., Masignani V.;
RT   "Structure and dynamics of the pan-genome of Streptococcus pneumoniae and
RT   closely related species.";
RL   Genome Biol. 11:R107.1-R107.19(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP000918; ACO17839.1; -; Genomic_DNA.
DR   RefSeq; WP_000009387.1; NC_012468.1.
DR   AlphaFoldDB; C1CAV7; -.
DR   SMR; C1CAV7; -.
DR   EnsemblBacteria; ACO17839; ACO17839; SP70585_2238.
DR   KEGG; snm:SP70585_2238; -.
DR   HOGENOM; CLU_044465_1_0_9; -.
DR   OMA; TDHGHPT; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000002211; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..466
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000147693"
SQ   SEQUENCE   466 AA;  54125 MW;  50D4CD68F8D45785 CRC64;
     MSFNDKNFML KNEPAKELYV KIAELPIYDF HCHLDPKEIF EDKVYEDIVD LWLGGDHYKW
     RLMRANGISE EEITGFASKL DKFKAWARTL ERAFGNPLYH WSHLELRQVF GIEELLTEEN
     AERLYHQLNT YLQEHQISPR KLIADARVAF IGTTDHPLDN LEWHKRLAED SPIDTVVAPT
     FRPDEAFIEH RNFNLFIKRL EEVTEVAVRD FASFVEALGQ RVSYFAQHGC RASDISFTAI
     TYEEATLEEL NDILLARMVG KEVGQSGINK WQTAIFRELC RMYKKHGFVT QVHFGALRNN
     HTGLFEKLGA DVGVDSIGDQ TCLTGNLNRL LDNLVKENAL PKMIWYNLNP GYNIALANTL
     ANFQANEEGR RSQLQFGAGW WFNDTKLGMI DQMNAYAEQG MLANFVGMLT DSRSFLSYQR
     HDYFRRILAT YVGQWIVDEE VPEDYDRLGQ FVEAISYYNA KEFFEQ