ID   CAH10_MOUSE             Reviewed;         328 AA.
AC   P61215;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2004, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Carbonic anhydrase-related protein 10;
DE   AltName: Full=Carbonic anhydrase-related protein X;
DE            Short=CA-RP X;
DE            Short=CARP X;
GN   Name=Ca10; Synonyms=Car10;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Taniuchi K., Nishimori I.;
RT   "Divelopmental expression of murine carbonic anhydrase-related protein
RT   VIII, X, and XI.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Does not have a catalytic activity.
CC   -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
CC       {ECO:0000305}.
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DR   EMBL; AB080741; BAC11853.1; -; mRNA.
DR   EMBL; BC017606; AAH17606.1; -; mRNA.
DR   CCDS; CCDS25244.1; -.
DR   RefSeq; NP_082572.1; NM_028296.3.
DR   RefSeq; XP_006534382.1; XM_006534319.3.
DR   RefSeq; XP_017170284.1; XM_017314795.1.
DR   AlphaFoldDB; P61215; -.
DR   SMR; P61215; -.
DR   STRING; 10090.ENSMUSP00000103495; -.
DR   GlyConnect; 2182; 3 N-Linked glycans (2 sites).
DR   GlyGen; P61215; 2 sites, 3 N-linked glycans (2 sites).
DR   PhosphoSitePlus; P61215; -.
DR   PaxDb; P61215; -.
DR   PRIDE; P61215; -.
DR   Antibodypedia; 30804; 205 antibodies from 27 providers.
DR   DNASU; 72605; -.
DR   Ensembl; ENSMUST00000042943; ENSMUSP00000035585; ENSMUSG00000056158.
DR   Ensembl; ENSMUST00000107863; ENSMUSP00000103495; ENSMUSG00000056158.
DR   GeneID; 72605; -.
DR   KEGG; mmu:72605; -.
DR   UCSC; uc007kxi.2; mouse.
DR   CTD; 72605; -.
DR   MGI; MGI:1919855; Car10.
DR   VEuPathDB; HostDB:ENSMUSG00000056158; -.
DR   eggNOG; KOG0382; Eukaryota.
DR   GeneTree; ENSGT00940000155223; -.
DR   HOGENOM; CLU_039326_7_1_1; -.
DR   InParanoid; P61215; -.
DR   OMA; HKNQNAC; -.
DR   OrthoDB; 1377476at2759; -.
DR   PhylomeDB; P61215; -.
DR   TreeFam; TF352926; -.
DR   BioGRID-ORCS; 72605; 5 hits in 73 CRISPR screens.
DR   ChiTaRS; Car10; mouse.
DR   PRO; PR:P61215; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; P61215; protein.
DR   Bgee; ENSMUSG00000056158; Expressed in cerebellum lobe and 114 other tissues.
DR   ExpressionAtlas; P61215; baseline and differential.
DR   Genevisible; P61215; MM.
DR   GO; GO:0004089; F:carbonate dehydratase activity; IEA:InterPro.
DR   GO; GO:0016836; F:hydro-lyase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006730; P:one-carbon metabolic process; IBA:GO_Central.
DR   CDD; cd03121; alpha_CARP_X_XI_like; 1.
DR   Gene3D; 3.10.200.10; -; 1.
DR   InterPro; IPR041878; Alpha_CARP_X/XI.
DR   InterPro; IPR018423; CA10.
DR   InterPro; IPR001148; CA_dom.
DR   InterPro; IPR036398; CA_dom_sf.
DR   InterPro; IPR023561; Carbonic_anhydrase_a-class.
DR   PANTHER; PTHR18952; PTHR18952; 1.
DR   PANTHER; PTHR18952:SF91; PTHR18952:SF91; 1.
DR   Pfam; PF00194; Carb_anhydrase; 1.
DR   SMART; SM01057; Carb_anhydrase; 1.
DR   SUPFAM; SSF51069; SSF51069; 1.
DR   PROSITE; PS51144; ALPHA_CA_2; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..328
FT                   /note="Carbonic anhydrase-related protein 10"
FT                   /id="PRO_0000077438"
FT   DOMAIN          31..301
FT                   /note="Alpha-carbonic anhydrase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01134"
SQ   SEQUENCE   328 AA;  37563 MW;  B20BFEC1800422B4 CRC64;
     MEIVWEVLFL LQANFIVCIS AQQNSPKIHE GWWAYKEVVQ GSFVPVPSFW GLVNSAWNLC
     SVGKRQSPVN IETSHMIFDP FLTPLRINTG GRKVSGTMYN TGRHVSLRLD KEHLVNISGG
     PMTYSHRLEE IRLHFGSEDS QGSEHLLNGQ AFSGEVQLIH YNHELYTNVT EAAKSPNGLV
     VVSIFIKVSD SSNPFLNRML NRDTITRITY KNDAYLLQGL NIEELYPETS SFITYDGSMT
     IPPCYETASW IIMNKPVYIT RMQMHSLRLL SQNQPSQIFL SMSDNFRPVQ PLNNRCIRTN
     INFSLQGKDC PNNRAQKLQY RVNEWLLK