ID   UXAC_THENN              Reviewed;         451 AA.
AC   B9K773;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=CTN_0630;
OS   Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=309803;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E;
RA   Lim S.K., Kim J.S., Cha S.H., Park B.C., Lee D.S., Tae H.S., Kim S.-J.,
RA   Kim J.J., Park K.J., Lee S.Y.;
RT   "The genome sequence of the hyperthermophilic bacterium Thermotoga
RT   neapolitana.";
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP000916; ACM22806.1; -; Genomic_DNA.
DR   RefSeq; WP_015919125.1; NC_011978.1.
DR   AlphaFoldDB; B9K773; -.
DR   SMR; B9K773; -.
DR   STRING; 309803.CTN_0630; -.
DR   EnsemblBacteria; ACM22806; ACM22806; CTN_0630.
DR   KEGG; tna:CTN_0630; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_0; -.
DR   OMA; TDHGHPT; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000000445; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..451
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000147695"
SQ   SEQUENCE   451 AA;  52379 MW;  442B07E85470C9F9 CRC64;
     MFLGEDYLLT NRAAVRLFSE VKDLPIVDPH NHLDAKDIVE NKPWNDIWEV EGATDHYVWE
     LMRRCGVPEE YITGSRSNRE KWLALAKVFP KFVGNPTYEW IHLDLWRRFN VKKVISEETA
     EEIWEETKRM LPEMTPQKLL KDMKVEILCT TDDPISTLEY HRKARETIKD VTILPTWRPD
     RAMNVEKSDW KDYVKKIGEI YNEDTSTLEG FLSALWKSHE HFKEHGCVAS DHALLEPSIH
     FVGEKTARKI HEKVFRGKEL DPEEIRDYKA FMMVQFGKMN QETGWVTQLH IGALRDYRDS
     LLKTLGPDSG GDISTNFLKI AEGLRYFLNE FDGKLKIVLY VLDPTHLPTI ATIARAFPNV
     YIGAPWWFND SPFGMEMHLK YVASVDLLYN LAGMVTDSRK LLSFGSRTEM FRRVLSSVVG
     EMVERGQIPI REAKELVKHV CYDGPKALFF G