ID   UXAC_THESQ              Reviewed;         451 AA.
AC   B1LA87;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=TRQ2_0883;
OS   Thermotoga sp. (strain RQ2).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga;
OC   unclassified Thermotoga.
OX   NCBI_TaxID=126740;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RQ2;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D.B., Goodwin L., Pitluck S., Saunders E., Brettin T.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Nelson K., Gogarten J.P., Noll K.,
RA   Richardson P.;
RT   "Complete sequence of Thermotoga sp. RQ2.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP000969; ACB09235.1; -; Genomic_DNA.
DR   RefSeq; WP_012310799.1; NC_010483.1.
DR   AlphaFoldDB; B1LA87; -.
DR   SMR; B1LA87; -.
DR   EnsemblBacteria; ACB09235; ACB09235; TRQ2_0883.
DR   KEGG; trq:TRQ2_0883; -.
DR   HOGENOM; CLU_044465_1_0_0; -.
DR   OMA; TDHGHPT; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001687; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..451
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000131611"
SQ   SEQUENCE   451 AA;  52393 MW;  7C535621D8CE9CF2 CRC64;
     MFLGEDYLLT NRAAVRLFNE VKDLPIVDPH NHLDAKDIVE NKPWSDIWEV EGATDHYVWE
     LMRRCGISEE YITGSRSNKE KWLALAKVFP RFVGNPTYEW IHLDLWRRFN IKKVISEETA
     EEIWEETKKK LPEMTPQKLL RDMKVEILCT TDDPVSTLEH HRKAKEVVEG VTILPTWRPD
     RAMNVDKEGW KEYVEKMGER YGEDTSTLEG FLSALWKSHE HFKEHGCVAS DHALLEPSVY
     YVDENRARAV HEKAFSGEKL TQDEINDYKA FMMIQFGKMN QETNWVTQLH IGALRDYRDS
     LFKTLGPDSG GDISTNFLRI AEGLRYFLNE FDGKLKIVLY VLDPTHLPTI ATIARAFPNV
     YVGAPWWFND SPFGMEMHLK YLASVDLLYN LAGMVTDSRK LLSFGSRTEM FRRVLSNVVG
     EMVEKGQIPI KEARELVKHV SYDGPKSLFF R