ID   UXAC_VIBPA              Reviewed;         470 AA.
AC   Q87FH3;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=VPA1706;
OS   Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=223926;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RIMD 2210633;
RX   PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA   Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA   Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA   Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT   "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT   distinct from that of V. cholerae.";
RL   Lancet 361:743-749(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; BA000032; BAC63049.1; -; Genomic_DNA.
DR   RefSeq; NP_801216.1; NC_004605.1.
DR   RefSeq; WP_005477444.1; NC_004605.1.
DR   AlphaFoldDB; Q87FH3; -.
DR   SMR; Q87FH3; -.
DR   STRING; 223926.28810108; -.
DR   EnsemblBacteria; BAC63049; BAC63049; BAC63049.
DR   GeneID; 1192402; -.
DR   KEGG; vpa:VPA1706; -.
DR   PATRIC; fig|223926.6.peg.4622; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_6; -.
DR   OMA; IWHQCNE; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000002493; Chromosome 2.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..470
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172791"
SQ   SEQUENCE   470 AA;  53987 MW;  61A064C622AC735E CRC64;
     MKNFLCEDFL LSNETARRLY HEHAFHQPIY DYHCHLNPAE VTQNRQFDNL GQIWLEGDHY
     KWRGMRSAGI EERLITGDAS DYDKYMAWAK TVPQTLGNPL YHWTHLELRR PFGITNTLFS
     PDTADQIWHQ CNELLATPEF TARGIMQQMN VVMAGTTDDP IDSLEHHKAI AEDDTFNVKV
     LPSWRPDKAF KIELDLFADY MHKLGEVADI DIRRFDDLLS ALDKRLAHFD SHGCRAADHG
     IEIVRYAPIP SEADLDALLA RRLSGEVLSE LECAQFSTAV QVWLGKRYAQ LGWVMQLHIG
     AQRNNSTRMF QLLGADAGFD SIGDRPFAFE LAHLLDEMDQ TNELPRTILY CLNPRDNEMM
     ATMIGNFQGG GIAGKVQFGS GWWFNDQKDG MQRQMEQLSQ LGLLSQFVGM LTDSRSFLSY
     TRHEYFRRIL CDMVGRWAEN GEVPNDLSLL GPMVEDICFG NAKRYFEERA