ID   UXAC_VIBVU              Reviewed;         470 AA.
AC   Q8D556;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=VV2_1070;
OS   Vibrio vulnificus (strain CMCP6).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=216895;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CMCP6;
RA   Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.;
RT   "Complete genome sequence of Vibrio vulnificus CMCP6.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; AE016796; AAO07977.1; -; Genomic_DNA.
DR   RefSeq; WP_011081971.1; NC_004460.2.
DR   AlphaFoldDB; Q8D556; -.
DR   SMR; Q8D556; -.
DR   EnsemblBacteria; AAO07977; AAO07977; VV2_1070.
DR   KEGG; vvu:VV2_1070; -.
DR   HOGENOM; CLU_044465_1_0_6; -.
DR   OMA; IWHQCNE; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000002275; Chromosome 2.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..470
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172792"
SQ   SEQUENCE   470 AA;  54023 MW;  B32E80E3D98BD5BE CRC64;
     MKNFLCEDFL LSNETARRLY HEHACHQPIY DYHCHLNPAE VAQNRQFDNL GQIWLEGDHY
     KWRGMRSAGI EERLITGDAS DYDKYMAWAK TVPQTLGNPL YHWTHLELRR PFGITNTLFS
     PDTADQIWHQ CNELLATPEF TARGIMQQMN VVMAGTTDDP IDSLKHHKTI AEDDTFNVKV
     LPSWRPDKAF KIELDLFADY MHKLGEVADI EIRRFDDLLS ALDKRLAHFD AHGCRAADHG
     IEIVRYAPIP SEADLDVLLA RRLNGEVLSE LECAQFSTAV QVWLGKRYAQ LGWVMQLHIG
     AQRNNSTRMF QLLGADAGFD SIGDRPFAFE LAHLLDEMDQ TNELPRTILY CLNPRDNEMM
     ATMIGNFQGG GIAGKVQFGS GWWFNDQKDG MQRQMEQLSQ LGLLSQFVGM LTDSRSFLSY
     TRHEYFRRIL CDMVGRWAEN GEVPNDLSLL GPMVEDICFG NAKRYFEERV