ID   UXAC_VIBVY              Reviewed;         470 AA.
AC   Q7MBZ3;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=VVA1594;
OS   Vibrio vulnificus (strain YJ016).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=196600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJ016;
RX   PubMed=14656965; DOI=10.1101/gr.1295503;
RA   Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L.,
RA   Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P.,
RA   Lee C.-T., Hor L.-I., Tsai S.-F.;
RT   "Comparative genome analysis of Vibrio vulnificus, a marine pathogen.";
RL   Genome Res. 13:2577-2587(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; BA000038; BAC97620.1; -; Genomic_DNA.
DR   RefSeq; WP_011152793.1; NC_005140.1.
DR   AlphaFoldDB; Q7MBZ3; -.
DR   SMR; Q7MBZ3; -.
DR   STRING; 672.VV93_v1c44640; -.
DR   EnsemblBacteria; BAC97620; BAC97620; BAC97620.
DR   KEGG; vvy:VVA1594; -.
DR   PATRIC; fig|196600.6.peg.4724; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_6; -.
DR   OMA; IWHQCNE; -.
DR   OrthoDB; 167900at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000002675; Chromosome II.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..470
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172793"
SQ   SEQUENCE   470 AA;  53911 MW;  5E7F42F8C1EBAD3E CRC64;
     MKNFLCEDFL LSNETARRLY HEHAFHQPIY DYHCHLNPAE VAQNRQFDNL GQIWLEGDHY
     KWRGMRSAGI EERLITGDAS DYDKYMAWAK TVPQTLGNPL YHWTHLELRR PFGITNALFS
     PDTADQIWHQ CNELLATPEF TARGIMQQMN VVMAGTTDDP IDSLEHHKAI AEDDTFNVKV
     LPSWRPDKAF KIELDVFADY MHKLGEVADI EIRRFDDLLS ALDKRLAHFD AHGCRAADHG
     IEIVRYAPIP SEADLDALLA RRLSGEVLSE LECAQFSTAV QVWLGKRYAQ LGWVMQLHIG
     AQRNNSTRMF QLLGADAGFD SIGDRPFAFE LAHLLDEMDQ TNELPRTILY CLNPRDNEMM
     ATMIGNFQGG GIAGKVQFGS GWWFNDQKDG MQRQMEQLSQ LGLLSQFVGM LTDSRSFLSY
     TRHEYFRRIL CDMVGRWAEN GEVPNDLSLL GPMVEDICFG NAKRYFEERA