UXAC_XANC8
ID UXAC_XANC8 Reviewed; 471 AA.
AC Q4UNX6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=XC_4209;
OS Xanthomonas campestris pv. campestris (strain 8004).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Xanthomonas.
OX NCBI_TaxID=314565;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=8004;
RX PubMed=15899963; DOI=10.1101/gr.3378705;
RA Qian W., Jia Y., Ren S.-X., He Y.-Q., Feng J.-X., Lu L.-F., Sun Q.,
RA Ying G., Tang D.-J., Tang H., Wu W., Hao P., Wang L., Jiang B.-L., Zeng S.,
RA Gu W.-Y., Lu G., Rong L., Tian Y., Yao Z., Fu G., Chen B., Fang R.,
RA Qiang B., Chen Z., Zhao G.-P., Tang J.-L., He C.;
RT "Comparative and functional genomic analyses of the pathogenicity of
RT phytopathogen Xanthomonas campestris pv. campestris.";
RL Genome Res. 15:757-767(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR EMBL; CP000050; AAY51247.1; -; Genomic_DNA.
DR RefSeq; WP_011039186.1; NC_007086.1.
DR AlphaFoldDB; Q4UNX6; -.
DR SMR; Q4UNX6; -.
DR EnsemblBacteria; AAY51247; AAY51247; XC_4209.
DR KEGG; xcb:XC_4209; -.
DR HOGENOM; CLU_044465_0_0_6; -.
DR OMA; TDHGHPT; -.
DR OrthoDB; 167900at2; -.
DR UniPathway; UPA00246; -.
DR Proteomes; UP000000420; Chromosome.
DR GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR HAMAP; MF_00675; UxaC; 1.
DR InterPro; IPR032466; Metal_Hydrolase.
DR InterPro; IPR003766; Uronate_isomerase.
DR Pfam; PF02614; UxaC; 1.
DR SUPFAM; SSF51556; SSF51556; 1.
PE 3: Inferred from homology;
KW Isomerase.
FT CHAIN 1..471
FT /note="Uronate isomerase"
FT /id="PRO_1000044782"
SQ SEQUENCE 471 AA; 52891 MW; 0D6A09D3AA91C469 CRC64;
MPTPLILHDD RLLPADPATR AIARRLYAQT AALPIISPHG HTDPAWFATD APFANATELL
LVPDHYVFRM LYSQGIDLDQ LGIPHADGSR APVDPREAWR VFASQFALLR GTPSALWLNH
VFHQVFDLRI RLDAGSADHY YDHITAALQT PAFRPRALFE RFNIEVIATT ESPLDTLEHH
ATIRDSGWTG RVLTAYRPDA VVDPEHEQFA SALQQFAALT GEDVMQWPGY LCAHRQRRAF
FAAAGATSTD HGHPSAATAD LSPAEAQRLF DTVVRGQATP AQAELFRAQV LTEMAAMSVD
DGLVMQLHPG CFRNHNRQLF ERYGRDKGAD IPMRTDYVHA LKPLLDRFGN DPRFRLIVFT
LDETSYSREL APLAGHYPAL LLGPAWWFHD APEGMWRFRE QTLASAGFYN TVGFNDDTRA
FLSIPARHDV ARRVDSAFLA KLVAEHRLDE DEAMEVAIDL AYRLPKQAYK L