ID   UXAC_XANCB              Reviewed;         471 AA.
AC   B0RZ13;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675};
GN   OrderedLocusNames=xcc-b100_4329;
OS   Xanthomonas campestris pv. campestris (strain B100).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=509169;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B100;
RX   PubMed=18304669; DOI=10.1016/j.jbiotec.2007.12.013;
RA   Vorhoelter F.-J., Schneiker S., Goesmann A., Krause L., Bekel T.,
RA   Kaiser O., Linke B., Patschkowski T., Rueckert C., Schmid J., Sidhu V.K.,
RA   Sieber V., Tauch A., Watt S.A., Weisshaar B., Becker A., Niehaus K.,
RA   Puehler A.;
RT   "The genome of Xanthomonas campestris pv. campestris B100 and its use for
RT   the reconstruction of metabolic pathways involved in xanthan
RT   biosynthesis.";
RL   J. Biotechnol. 134:33-45(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; AM920689; CAP53699.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0RZ13; -.
DR   SMR; B0RZ13; -.
DR   KEGG; xca:xcc-b100_4329; -.
DR   HOGENOM; CLU_044465_0_0_6; -.
DR   OMA; TDHGHPT; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001188; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..471
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000131614"
SQ   SEQUENCE   471 AA;  52859 MW;  A46AD73B6A5C1DAF CRC64;
     MPTPLILHDD RLLPADPATR AIARRLYAQT AALPIISPHG HTDPAWFATD APFANATELL
     LVPDHYVFRM LYSQGIDLDQ LGIPHADGSR APVDPREAWR VFASQFALLR GTPSALWLNH
     VFHQVFDLRI RLDAGSADHY YDHITAALQT PAFRPRALFE RFNIEVIATT ESPLDTLEHH
     ATIRDSGWSG RVLTAYRPDA VVDPEHEQFA SALQQFGALT GEDVMQWPGY LRAHRQRRAF
     FAAAGATSTD HGHPSAATAD LSPAEAQRLF DTVVRGQATP AQAELFRAQV LTEMAAMSVD
     DGLVMQLHPG CFRNHNRALF ERYGRDKGAD IPMRTDYVHA LKPLLDRFGN DPRFRLIVFT
     LDETSYSREL APLAGHYPAL LLGPAWWFHD APEGMWRFRE QTLASAGFYN TVGFNDDTRA
     FLSIPARHDV ARRVDSAFLA KLVAEHRLDE DEAMEVAIDL AYRLPKQAYK L