ID   UXAC_XANOM              Reviewed;         472 AA.
AC   Q2NXQ2;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=XOO4170;
OS   Xanthomonas oryzae pv. oryzae (strain MAFF 311018).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=342109;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MAFF 311018;
RA   Ochiai H., Inoue Y., Takeya M., Sasaki A., Kaku H.;
RT   "Genome sequence of Xanthomonas oryzae pv. oryzae suggests contribution of
RT   large numbers of effector genes and insertion sequences to its race
RT   diversity.";
RL   Jpn. Agric. Res. Q. 39:275-287(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; AP008229; BAE70925.1; -; Genomic_DNA.
DR   RefSeq; WP_011260712.1; NC_007705.1.
DR   AlphaFoldDB; Q2NXQ2; -.
DR   SMR; Q2NXQ2; -.
DR   KEGG; xom:XOO4170; -.
DR   HOGENOM; CLU_044465_0_0_6; -.
DR   OMA; TDHGHPT; -.
DR   UniPathway; UPA00246; -.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..472
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000131615"
SQ   SEQUENCE   472 AA;  52729 MW;  78DFBACBF0AF9519 CRC64;
     MRSSVLSLHP DRLLPADPGT RAIAGRLYAQ IATLPIISPH GHTDPAWFAT NAPFADATEL
     LLVPDHYVFR MLYSQGIDLD AIGIPRADGM RAAVDPRAAW RVFAAHYTVL RGTPSALWLN
     HVFHDVFDLR LRLDAGTADH YYDHITAALQ TPDFLPRALF ERFNIEVIAT TESPLDPLHH
     HAAIAASGWQ GRVVTAYRPD PVVDPEHAQF AGALQQFGAL TGEDVLTWNG YLRAHRQRRA
     FFAAHGATST DHGHPSAATA DLSPAQAQRL FDTVVRGAAT PEQAELFRAQ VLTEMAAMSL
     DDGLVMQLHP GCFRNHNRPL FERYGRDKGA DIPMRTDYVH ALKPLLDRYG NDPRLRLIVF
     TLDETSYSRE LAPLAGHYPS LLLGPAWWFH DAPEGMWRFR EQTLASAGFY NTVGFNDDTR
     AFLSIPARHD VARRVDSAFL AKLVAEHRLE EDEATEVAID LAYRMPKRAY NL