ID   UXAC_XANOR              Reviewed;         472 AA.
AC   Q9AM27; Q5GUE2;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 2.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; Synonyms=hrmI;
GN   OrderedLocusNames=XOO4427;
OS   Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=291331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Rajeshwari R., Sonti R.V.;
RT   "Xylanase gene from Xanthomonas oryzae pv. oryzae.";
RL   Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KACC10331 / KXO85;
RX   PubMed=15673718; DOI=10.1093/nar/gki206;
RA   Lee B.-M., Park Y.-J., Park D.-S., Kang H.-W., Kim J.-G., Song E.-S.,
RA   Park I.-C., Yoon U.-H., Hahn J.-H., Koo B.-S., Lee G.-B., Kim H.,
RA   Park H.-S., Yoon K.-O., Kim J.-H., Jung C.-H., Koh N.-H., Seo J.-S.,
RA   Go S.-J.;
RT   "The genome sequence of Xanthomonas oryzae pathovar oryzae KACC10331, the
RT   bacterial blight pathogen of rice.";
RL   Nucleic Acids Res. 33:577-586(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAW77681.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF331922; AAK01134.1; -; Genomic_DNA.
DR   EMBL; AE013598; AAW77681.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_011260712.1; NC_006834.1.
DR   AlphaFoldDB; Q9AM27; -.
DR   SMR; Q9AM27; -.
DR   STRING; 291331.XOO4427; -.
DR   EnsemblBacteria; AAW77681; AAW77681; XOO4427.
DR   KEGG; xoo:XOO4427; -.
DR   PATRIC; fig|291331.8.peg.4917; -.
DR   HOGENOM; CLU_044465_0_0_6; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000006735; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..472
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172796"
FT   CONFLICT        208
FT                   /note="A -> E (in Ref. 1; AAK01134)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        353
FT                   /note="P -> R (in Ref. 1; AAK01134)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        457
FT                   /note="V -> L (in Ref. 1; AAK01134)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        461
FT                   /note="L -> M (in Ref. 1; AAK01134)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   472 AA;  52729 MW;  78DFBACBF0AF9519 CRC64;
     MRSSVLSLHP DRLLPADPGT RAIAGRLYAQ IATLPIISPH GHTDPAWFAT NAPFADATEL
     LLVPDHYVFR MLYSQGIDLD AIGIPRADGM RAAVDPRAAW RVFAAHYTVL RGTPSALWLN
     HVFHDVFDLR LRLDAGTADH YYDHITAALQ TPDFLPRALF ERFNIEVIAT TESPLDPLHH
     HAAIAASGWQ GRVVTAYRPD PVVDPEHAQF AGALQQFGAL TGEDVLTWNG YLRAHRQRRA
     FFAAHGATST DHGHPSAATA DLSPAQAQRL FDTVVRGAAT PEQAELFRAQ VLTEMAAMSL
     DDGLVMQLHP GCFRNHNRPL FERYGRDKGA DIPMRTDYVH ALKPLLDRYG NDPRLRLIVF
     TLDETSYSRE LAPLAGHYPS LLLGPAWWFH DAPEGMWRFR EQTLASAGFY NTVGFNDDTR
     AFLSIPARHD VARRVDSAFL AKLVAEHRLE EDEATEVAID LAYRMPKRAY NL