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UXAC_YERE8
ID   UXAC_YERE8              Reviewed;         469 AA.
AC   A1JR25;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=YE3708;
OS   Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 /
OS   8081).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=393305;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 13174 / 8081;
RX   PubMed=17173484; DOI=10.1371/journal.pgen.0020206;
RA   Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L.,
RA   Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T.,
RA   Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S.,
RA   Sanders M., Whitehead S., Quail M.A., Dougan G., Parkhill J.,
RA   Prentice M.B.;
RT   "The complete genome sequence and comparative genome analysis of the high
RT   pathogenicity Yersinia enterocolitica strain 8081.";
RL   PLoS Genet. 2:2039-2051(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; AM286415; CAL13735.1; -; Genomic_DNA.
DR   RefSeq; WP_005174193.1; NC_008800.1.
DR   RefSeq; YP_001007863.1; NC_008800.1.
DR   AlphaFoldDB; A1JR25; -.
DR   SMR; A1JR25; -.
DR   STRING; 393305.YE3708; -.
DR   EnsemblBacteria; CAL13735; CAL13735; YE3708.
DR   KEGG; yen:YE3708; -.
DR   PATRIC; fig|393305.7.peg.3948; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_6; -.
DR   OMA; TDHGHPT; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000000642; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..469
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000044783"
SQ   SEQUENCE   469 AA;  53408 MW;  AA888F7E91691231 CRC64;
     MAQFLTEDFL LDTEFARRLY HDYAKDQPIY DYHCHLPPEQ IAENTRFKNL YDIWLKGDHY
     KWRAMRTNGV AERFCTGDAS DREKFDAWAA TVPHTIGNPL YHWTHLELRR PFGITGKLLS
     PATADEIWQR GNELLAQDSF SARGIMQKMN VKMVGTTDDP IDDLRHHKAI AADGSFNIKV
     LPSWRPDKAF NIEAAGFNDY MQRLEAAADT SISRFADLCT ALNKRMDHFA AHGCKVSDHA
     LDVVVYGEAD EATLDGILAR RLAGNQPSTE ETAQFKTAVL LFLSGEYHRR EWVQQYHIGA
     LRNNNSRMFN LVGPDIGFDS INDQPLAQPL SRLLDAQGLR NALPKTILYC LNPRDNEVIG
     TMVGNFQGEG AAGKMQFGSG WWFNDQKDGM QRQMTQLAQL GLLSRFVGML TDSRSFLSYT
     RHEYFRRILC QMIGRWVEDG EAPADIELLG SMVKNICFDN AKQYFAIEL
 
 
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