UXAC_YERPA
ID UXAC_YERPA Reviewed; 469 AA.
AC Q1C300;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; OrderedLocusNames=YPA_3210;
OS Yersinia pestis bv. Antiqua (strain Antiqua).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=360102;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Antiqua;
RX PubMed=16740952; DOI=10.1128/jb.00124-06;
RA Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M.,
RA Worsham P., Chu M.C., Andersen G.L.;
RT "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516:
RT evidence of gene reduction in an emerging pathogen.";
RL J. Bacteriol. 188:4453-4463(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR EMBL; CP000308; ABG15172.1; -; Genomic_DNA.
DR RefSeq; WP_002210410.1; NZ_CP009906.1.
DR AlphaFoldDB; Q1C300; -.
DR SMR; Q1C300; -.
DR EnsemblBacteria; ABG15172; ABG15172; YPA_3210.
DR GeneID; 66844103; -.
DR KEGG; ypa:YPA_3210; -.
DR OMA; TDHGHPT; -.
DR UniPathway; UPA00246; -.
DR Proteomes; UP000001971; Chromosome.
DR GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR HAMAP; MF_00675; UxaC; 1.
DR InterPro; IPR032466; Metal_Hydrolase.
DR InterPro; IPR003766; Uronate_isomerase.
DR Pfam; PF02614; UxaC; 1.
DR SUPFAM; SSF51556; SSF51556; 1.
PE 3: Inferred from homology;
KW Isomerase.
FT CHAIN 1..469
FT /note="Uronate isomerase"
FT /id="PRO_1000044784"
SQ SEQUENCE 469 AA; 53475 MW; 2C5392F06BDA9803 CRC64;
MSQFLTEDFL LDTEFARRLY HDYAKDQPIF DYHCHLPPEQ IAENYRFKNM YDIWLKGDHY
KWRAMRTNGV AERLCTGDAS DREKFDAWAA TVPHTIGNPL YHWTHLELRR PFGITGKLLS
PATSEEIWQR GNELLAQDPF SARGIMQQMN VKMVGTTDDP IDDLRHHKAI AADGSFNIKV
LPSWRPDKAF NIEAAGFNDY MQRLEAAADT SISRFADLCV ALNKRMDHFA AHGCKVSDHA
LDVVVYGEAD ETTLDAILAR RLAGNQPSTE EIAQFKTAVL LFLSGEYHRR EWVQQYHIGA
LRNNNSRMFN LVGPDIGFDS INDQPLAQPL SRLLDAQGLR NALPKTILYC LNPRDNEVIG
TMVGNFQGEG EAGKMQFGSG WWFNDQKDGM QRQMTQLAQL GLLSRFVGML TDSRSFLSYT
RHEYFRRILC QMIGRWVADG EAPADIALLG AMVKNICFDN AQQYFAIEL