ID   UXP_ADE02               Reviewed;         217 AA.
AC   P0DJX2;
DT   06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2013, sequence version 1.
DT   23-FEB-2022, entry version 15.
DE   RecName: Full=U exon protein;
DE            Short=UXP;
OS   Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus.
OX   NCBI_TaxID=10515;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-55.
RX   PubMed=455453; DOI=10.1016/0092-8674(79)90100-4;
RA   Zain S., Sambrook J., Roberts R.J., Keller W., Fried M., Dunn A.R.;
RT   "Nucleotide sequence analysis of the leader segments in a cloned copy of
RT   adenovirus 2 fiber mRNA.";
RL   Cell 16:851-861(1979).
RN   [2]
RP   IDENTIFICATION, SUBCELLULAR LOCATION, AND FUNCTION.
RC   STRAIN=Human adenovirus C serotype 5;
RX   PubMed=17881437; DOI=10.1128/jvi.01531-07;
RA   Tollefson A.E., Ying B., Doronin K., Sidor P.D., Wold W.S.;
RT   "Identification of a new human adenovirus protein encoded by a novel late
RT   l-strand transcription unit.";
RL   J. Virol. 81:12918-12926(2007).
CC   -!- FUNCTION: Might play a role in viral replication since it is associated
CC       with viral replication centers. Seems to have an effect on DBP
CC       localization. {ECO:0000269|PubMed:17881437}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus, host nucleoplasm
CC       {ECO:0000269|PubMed:17881437}. Host nucleus, host nucleolus
CC       {ECO:0000269|PubMed:17881437}. Note=At 18 to 24 hours postinfection,
CC       UXP is strongly associated with nucleoli and is found throughout the
CC       nucleus. Later, UXP is associated with the periphery of replication
CC       centers.
CC   -!- INDUCTION: Expressed abundantly in the late phase of the viral
CC       replicative cycle.
CC   -!- SIMILARITY: Belongs to the adenoviridae U exon protein family.
CC       {ECO:0000305}.
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DR   EMBL; J01917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Proteomes; UP000008167; Genome.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044095; C:host cell nucleoplasm; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host nucleus; Late protein; Reference proteome.
FT   CHAIN           1..217
FT                   /note="U exon protein"
FT                   /id="PRO_0000421108"
FT   REGION          68..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          170..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..83
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        201..217
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   217 AA;  23510 MW;  8685C7C0A9E49BDD CRC64;
     MKIVGAEGQE HEEFDIPFKL WRKFAAKRRL RYQSWEEGKE VMLNKLDKDL LTDFKAFAAR
     FSSRPRPSKI FGTSSSEAIS GEGNGQSGRG AARNHPRART RCGATSTNHG GRVVPVAVAA
     ASPRAPKKAA EAASRVRGRR RLVTRCAGAA HTQPAAIDLD GGFGHCVQKE KEAPLSQARA
     PAIPRGDRGQ RGRKRRCGAT NGGFQQPTGA NQARQGR