ID   UXP_ADE05               Reviewed;         217 AA.
AC   A8W995;
DT   06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   29-SEP-2021, entry version 26.
DE   RecName: Full=U exon protein;
DE            Short=UXP;
OS   Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus.
OX   NCBI_TaxID=28285;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1727603; DOI=10.1016/0042-6822(92)90082-z;
RA   Chroboczek J., Bieber F., Jacrot B.;
RT   "The sequence of the genome of adenovirus type 5 and its comparison with
RT   the genome of adenovirus type 2.";
RL   Virology 186:280-285(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND FUNCTION.
RC   STRAIN=ATCC VR-5;
RX   PubMed=17881437; DOI=10.1128/jvi.01531-07;
RA   Tollefson A.E., Ying B., Doronin K., Sidor P.D., Wold W.S.;
RT   "Identification of a new human adenovirus protein encoded by a novel late
RT   l-strand transcription unit.";
RL   J. Virol. 81:12918-12926(2007).
CC   -!- FUNCTION: Might play a role in viral replication since it is associated
CC       with viral replication centers. Seems to have an effect on DBP
CC       localization. {ECO:0000269|PubMed:17881437}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus, host nucleoplasm
CC       {ECO:0000269|PubMed:17881437}. Host nucleus, host nucleolus
CC       {ECO:0000269|PubMed:17881437}. Note=At 18 to 24 hours postinfection,
CC       UXP is strongly associated with nucleoli and is found throughout the
CC       nucleus. Later, UXP is associated with the periphery of replication
CC       centers.
CC   -!- INDUCTION: Expressed abundantly in the late phase of the viral
CC       replicative cycle.
CC   -!- SIMILARITY: Belongs to the adenoviridae U exon protein family.
CC       {ECO:0000305}.
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DR   EMBL; M73260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; EU202643; ABW72885.1; -; mRNA.
DR   Proteomes; UP000004992; Genome.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044095; C:host cell nucleoplasm; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host nucleus; Late protein.
FT   CHAIN           1..217
FT                   /note="U exon protein"
FT                   /id="PRO_0000421141"
FT   REGION          79..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          171..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        201..217
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   217 AA;  23567 MW;  982660B203590A5F CRC64;
     MKIVGADGQE QEETDIPFRL WRKFAARRKL QYQSWEEGKE VLLNKLDRNL LTDFKAFAAR
     FSSRPRPSKI FGTSLSEAIS GEGNGQSGRG AARNHPRART RCGATSPNHG GRVVPVPVAA
     ASPGAPKKAD EAAYRVRGRG RLITRRAGAA HTQPAAIDLG GGFGHCAQEE KEAPFSQARA
     PAITRGNRGQ RGRKRRCGAT NGGFQQPTGA NQAWQRR