CAH11_MOUSE
ID CAH11_MOUSE Reviewed; 328 AA.
AC O70354; Q8VEA9;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 09-MAY-2003, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Carbonic anhydrase-related protein 11;
DE AltName: Full=CA-RP XI;
DE Short=CA-XI;
DE Short=CARP XI;
DE AltName: Full=Carbonic anhydrase-related protein 2;
DE Short=CA-RP II;
DE Short=CARP-2;
DE Flags: Precursor;
GN Name=Ca11; Synonyms=Car11, Carp2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Taniuchi K., Nishimori I.;
RT "A novel CA-RP XI gene.";
RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 48-251.
RC TISSUE=Brain;
RX PubMed=9878252; DOI=10.1006/geno.1998.5585;
RA Lovejoy D.A., Hewett-Emmett D., Porter C.A., Cepoi D., Sheffield A.,
RA Vale W.W., Tashian R.E.;
RT "Evolutionarily conserved, 'acatalytic' carbonic anhydrase-related protein
RT XI contains a sequence motif present in the neuropeptide sauvagine: the
RT human CA-RP XI gene (CA11) is embedded between the secretor gene cluster
RT and the DBP gene at 19q13.3.";
RL Genomics 54:484-493(1998).
CC -!- FUNCTION: Does not have a catalytic activity.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
CC {ECO:0000305}.
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DR EMBL; AB079601; BAC07262.1; -; mRNA.
DR EMBL; BC019393; AAH19393.1; -; mRNA.
DR EMBL; AF050105; AAD08801.1; -; mRNA.
DR CCDS; CCDS21259.1; -.
DR RefSeq; NP_033930.1; NM_009800.4.
DR AlphaFoldDB; O70354; -.
DR SMR; O70354; -.
DR STRING; 10090.ENSMUSP00000003360; -.
DR GlyConnect; 2183; 4 N-Linked glycans (2 sites).
DR GlyGen; O70354; 2 sites, 4 N-linked glycans (2 sites).
DR iPTMnet; O70354; -.
DR PhosphoSitePlus; O70354; -.
DR PaxDb; O70354; -.
DR PRIDE; O70354; -.
DR ProteomicsDB; 273896; -.
DR Antibodypedia; 31755; 116 antibodies from 24 providers.
DR DNASU; 12348; -.
DR Ensembl; ENSMUST00000003360; ENSMUSP00000003360; ENSMUSG00000003273.
DR GeneID; 12348; -.
DR KEGG; mmu:12348; -.
DR UCSC; uc009gwr.1; mouse.
DR CTD; 12348; -.
DR MGI; MGI:1336193; Car11.
DR VEuPathDB; HostDB:ENSMUSG00000003273; -.
DR eggNOG; KOG0382; Eukaryota.
DR GeneTree; ENSGT00940000162098; -.
DR HOGENOM; CLU_039326_7_0_1; -.
DR InParanoid; O70354; -.
DR OMA; FPMEIQL; -.
DR OrthoDB; 1377476at2759; -.
DR PhylomeDB; O70354; -.
DR TreeFam; TF352926; -.
DR BioGRID-ORCS; 12348; 1 hit in 73 CRISPR screens.
DR PRO; PR:O70354; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; O70354; protein.
DR Bgee; ENSMUSG00000003273; Expressed in superior frontal gyrus and 178 other tissues.
DR ExpressionAtlas; O70354; baseline and differential.
DR Genevisible; O70354; MM.
DR GO; GO:0016323; C:basolateral plasma membrane; IDA:UniProtKB.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016836; F:hydro-lyase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IBA:GO_Central.
DR CDD; cd03121; alpha_CARP_X_XI_like; 1.
DR Gene3D; 3.10.200.10; -; 1.
DR InterPro; IPR041878; Alpha_CARP_X/XI.
DR InterPro; IPR001148; CA_dom.
DR InterPro; IPR036398; CA_dom_sf.
DR InterPro; IPR023561; Carbonic_anhydrase_a-class.
DR PANTHER; PTHR18952; PTHR18952; 1.
DR Pfam; PF00194; Carb_anhydrase; 1.
DR SMART; SM01057; Carb_anhydrase; 1.
DR SUPFAM; SSF51069; SSF51069; 1.
DR PROSITE; PS51144; ALPHA_CA_2; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..328
FT /note="Carbonic anhydrase-related protein 11"
FT /id="PRO_0000004246"
FT DOMAIN 33..303
FT /note="Alpha-carbonic anhydrase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01134"
FT REGION 300..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 118
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 328 AA; 36051 MW; 483E9770CC4362FD CRC64;
MGGAARLSAP QALVLWAALG AAAHIGPAPD PEDWWSYKEN LQGNFVPGPP FWGLVNAAWS
LCAVGKRQSP VDVELKRVLY DPFLPPLRLS TGGEKLRGTL YNTGRHVSFL PASRPVVNVS
GGPLLYSHRL SELRLLFGAR DGAGSEHQIN HEGFSAEVQL IHFNQELYGN LSAASRGPNG
LAILSLFVNV AGSSNPFLSR LLNRDTITRI SYKNDAYFLQ DLSLELLFPE SFGFITYQGS
LSTPPCSETV TWILIDRALN ITSLQMHSLR LLSQNPPSQI FQSLSGNGRP LQPLAHRALR
GNRDPRHPER RCRGPNYRLH VDGGPHGR
