UXT_RAT
ID UXT_RAT Reviewed; 157 AA.
AC Q63ZY7;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Protein UXT;
DE AltName: Full=Ubiquitously expressed transcript protein;
GN Name=Uxt;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in gene transcription regulation. Acts in concert
CC with the corepressor URI1 to regulate androgen receptor AR-mediated
CC transcription. Together with URI1, associates with chromatin to the
CC NKX3-1 promoter region. Negatively regulates the transcriptional
CC activity of the estrogen receptor ESR1 by inducing its translocation
CC into the cytoplasm. May act as nuclear chaperone that facilitates the
CC formation of the NF-kappa-B enhanceosome and thus positively regulates
CC NF-kappa-B transcription activity. Potential component of
CC mitochondrial-associated LRPPRC, a multidomain organizer that
CC potentially integrates mitochondria and the microtubular cytoskeleton
CC with chromosome remodeling. Increasing concentrations of UXT
CC contributes to progressive aggregation of mitochondria and cell death
CC potentially through its association with LRPPRC. Suppresses cell
CC transformation and it might mediate this function by interaction and
CC inhibition of the biological activity of cell proliferation and
CC survival stimulatory factors like MECOM.
CC {ECO:0000250|UniProtKB:Q9UBK9}.
CC -!- SUBUNIT: Homohexamer. Component of the PAQosome complex which is
CC responsible for the biogenesis of several protein complexes and which
CC consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI
CC complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF,
CC POLR2E and DNAAF10/WDR92. Interacts with LRPPRC. Interacts with
CC androgen receptor AR (via N-terminus). Interacts with estrogen receptor
CC ESR1; the interaction relocalizes ESR1 to the cytoplasm. In the
CC nucleus, interacts specifically with RELA (via RHD domain) and forms a
CC dynamic complex with NF-kappa-B and is recruited to the NF-kappa-B
CC enhanceosome upon stimulation. Interacts with MECOM. Interacts with
CC URI1. {ECO:0000250|UniProtKB:Q9UBK9}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UBK9}. Nucleus
CC {ECO:0000250|UniProtKB:Q9UBK9}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000250|UniProtKB:Q9UBK9}.
CC Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9UBK9}.
CC Note=Predominantly localizes to the nucleus. Localizes to spindle pole
CC during mitosis. {ECO:0000250|UniProtKB:Q9UBK9}.
CC -!- SIMILARITY: Belongs to the UXT family. {ECO:0000305}.
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DR EMBL; BC082752; AAH82752.1; -; mRNA.
DR RefSeq; NP_001006983.1; NM_001006982.1.
DR RefSeq; XP_006256673.1; XM_006256611.3.
DR AlphaFoldDB; Q63ZY7; -.
DR SMR; Q63ZY7; -.
DR STRING; 10116.ENSRNOP00000013476; -.
DR PhosphoSitePlus; Q63ZY7; -.
DR jPOST; Q63ZY7; -.
DR PaxDb; Q63ZY7; -.
DR PRIDE; Q63ZY7; -.
DR Ensembl; ENSRNOT00000013476; ENSRNOP00000013476; ENSRNOG00000009893.
DR GeneID; 299313; -.
DR KEGG; rno:299313; -.
DR UCSC; RGD:1359326; rat.
DR CTD; 8409; -.
DR RGD; 1359326; Uxt.
DR eggNOG; KOG3047; Eukaryota.
DR GeneTree; ENSGT00390000018078; -.
DR HOGENOM; CLU_121199_1_0_1; -.
DR InParanoid; Q63ZY7; -.
DR OMA; NIFMQAR; -.
DR OrthoDB; 1559312at2759; -.
DR PhylomeDB; Q63ZY7; -.
DR TreeFam; TF323827; -.
DR PRO; PR:Q63ZY7; -.
DR Proteomes; UP000002494; Chromosome X.
DR Bgee; ENSRNOG00000009893; Expressed in ovary and 20 other tissues.
DR Genevisible; Q63ZY7; RN.
DR GO; GO:0005813; C:centrosome; ISS:HGNC-UCL.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005856; C:cytoskeleton; ISS:HGNC-UCL.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:1990062; C:RPAP3/R2TP/prefoldin-like complex; ISO:RGD.
DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR GO; GO:0048487; F:beta-tubulin binding; ISS:HGNC-UCL.
DR GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.
DR GO; GO:0007098; P:centrosome cycle; ISS:HGNC-UCL.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; ISS:HGNC-UCL.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.287.370; -; 1.
DR InterPro; IPR009053; Prefoldin.
DR InterPro; IPR004127; Prefoldin_subunit_alpha.
DR InterPro; IPR003994; UXT.
DR Pfam; PF02996; Prefoldin; 1.
DR PRINTS; PR01502; UXTPROTEIN.
PE 2: Evidence at transcript level;
KW Activator; Chaperone; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome;
KW Repressor; Transcription; Transcription regulation.
FT CHAIN 1..157
FT /note="Protein UXT"
FT /id="PRO_0000330760"
SQ SEQUENCE 157 AA; 18166 MW; EC681FEE8D97A625 CRC64;
MATPPKRRAL DTVGEKVLRY EAFISDVLQR DLQKVLDHRD KVYEQLSVYL QLRNVIERLQ
ETNHSELYMQ VDLGCNFFVD TMVPDTSRIY VALGYGFFLE LTLAEALKFI DRKSSLLTEL
SDSLTKDSMN IKANIHMMLE GLRELQGLQN FPEPSPH
