ID   UXUA1_ALKHC             Reviewed;         361 AA.
AC   Q9KDZ8;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Mannonate dehydratase 1;
DE            EC=4.2.1.8;
DE   AltName: Full=D-mannonate hydro-lyase 1;
GN   Name=uxuA1; OrderedLocusNames=BH1063;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- FUNCTION: Catalyzes the dehydration of D-mannonate. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O;
CC         Xref=Rhea:RHEA:20097, ChEBI:CHEBI:15377, ChEBI:CHEBI:17767,
CC         ChEBI:CHEBI:57990; EC=4.2.1.8;
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000250};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion.
CC   -!- SIMILARITY: Belongs to the mannonate dehydratase family. {ECO:0000305}.
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DR   EMBL; BA000004; BAB04782.1; -; Genomic_DNA.
DR   PIR; G83782; G83782.
DR   RefSeq; WP_010897233.1; NC_002570.2.
DR   AlphaFoldDB; Q9KDZ8; -.
DR   SMR; Q9KDZ8; -.
DR   STRING; 272558.10173678; -.
DR   EnsemblBacteria; BAB04782; BAB04782; BAB04782.
DR   KEGG; bha:BH1063; -.
DR   eggNOG; COG1312; Bacteria.
DR   HOGENOM; CLU_058621_1_0_9; -.
DR   OMA; GIVWALH; -.
DR   OrthoDB; 907794at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0008927; F:mannonate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00106; UxuA; 1.
DR   InterPro; IPR004628; Man_deHydtase.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   PANTHER; PTHR30387; PTHR30387; 1.
DR   Pfam; PF03786; UxuA; 1.
DR   PIRSF; PIRSF016049; Man_dehyd; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR00695; uxuA; 1.
PE   3: Inferred from homology;
KW   Iron; Lyase; Manganese; Reference proteome.
FT   CHAIN           1..361
FT                   /note="Mannonate dehydratase 1"
FT                   /id="PRO_0000170660"
SQ   SEQUENCE   361 AA;  41633 MW;  4C45A43278E1E732 CRC64;
     MRMVFRWFGA GNDSVSLAHI RQIPGVEGIV WALHDIPPGE VWPLSRIMEI KEQAEQHQFH
     IDVVESVNVH EDIKLGLPTR DRYIEAYKQT IKHLAKAGVK VICYNFMPVF DWVRTDLYKK
     LEDGSTALFY EKKEVDEMNP KGLVETIASN KTFTMPGWEP ERLASLKTLF EAYEHVSTED
     LWDHLHYFLQ EVIPVAEACD IKMAIHPDDP PWPIFGLPRI VTNHDNIRRL LKLVDHPTNG
     ITLCSGALGA DPNNQVPEMI REFADRIPFA HIRNIKRFDN GDFVETSHRE QDGSIDIVSI
     VKAYHEVGFT GYVRPDHGRH IWDEQCRPGY GLYDRALGIM YLWGIWDSVQ NGQRMHDLTA
     K