ID   UXUA2_ALKHC             Reviewed;         345 AA.
AC   Q9KEZ3;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Mannonate dehydratase 2;
DE            EC=4.2.1.8;
DE   AltName: Full=D-mannonate hydro-lyase 2;
GN   Name=uxuA2; OrderedLocusNames=BH0706;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- FUNCTION: Catalyzes the dehydration of D-mannonate. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O;
CC         Xref=Rhea:RHEA:20097, ChEBI:CHEBI:15377, ChEBI:CHEBI:17767,
CC         ChEBI:CHEBI:57990; EC=4.2.1.8;
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000250};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion.
CC   -!- SIMILARITY: Belongs to the mannonate dehydratase family. {ECO:0000305}.
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DR   EMBL; BA000004; BAB04425.1; -; Genomic_DNA.
DR   PIR; B83738; B83738.
DR   RefSeq; WP_010896879.1; NC_002570.2.
DR   AlphaFoldDB; Q9KEZ3; -.
DR   SMR; Q9KEZ3; -.
DR   STRING; 272558.10173320; -.
DR   EnsemblBacteria; BAB04425; BAB04425; BAB04425.
DR   KEGG; bha:BH0706; -.
DR   eggNOG; COG1312; Bacteria.
DR   HOGENOM; CLU_058621_1_0_9; -.
DR   OMA; AIVKAYH; -.
DR   OrthoDB; 907794at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0008927; F:mannonate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00106; UxuA; 1.
DR   InterPro; IPR004628; Man_deHydtase.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   PANTHER; PTHR30387; PTHR30387; 1.
DR   Pfam; PF03786; UxuA; 1.
DR   PIRSF; PIRSF016049; Man_dehyd; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR00695; uxuA; 1.
PE   3: Inferred from homology;
KW   Iron; Lyase; Manganese; Reference proteome.
FT   CHAIN           1..345
FT                   /note="Mannonate dehydratase 2"
FT                   /id="PRO_0000170661"
SQ   SEQUENCE   345 AA;  38888 MW;  E219AA943820EBEA CRC64;
     MRLTMRWFGP SDKVKLEYIK QIPGMKGIVS AIYDVAVGGV WPKEKILALK NNIERHGLTL
     DVIESVPVHE DIKLGKPTRD RYIENYKQTL RHLAECGIDT VCYNFMPVFD WTRSQLDFKL
     EDGSEALIYE EDVISRTNPL SGELELPGWD TSYENESLKG VLQAYKKISE EDLWDHLTYF
     VQAIMPVADE VGIKMAIHPD DPPWSIFGLP RIVTNKANLE RLLSLYDSPN HGITMCSGSL
     GANEANDLPE MIRHFGGQGR IHFAHARNIK RTGPRSFQES AHLSEAGSVN MVAMLKAYHD
     IGFTGPLRPD HGRMIWGEKG RPGYGLYDRA LGATYLNGIW EAVSS