ID   UXUA_BACFR              Reviewed;         396 AA.
AC   Q650A0;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 2.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Mannonate dehydratase {ECO:0000255|HAMAP-Rule:MF_00106};
DE            EC=4.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00106};
DE   AltName: Full=D-mannonate hydro-lyase {ECO:0000255|HAMAP-Rule:MF_00106};
GN   Name=uxuA {ECO:0000255|HAMAP-Rule:MF_00106}; OrderedLocusNames=BF0177;
OS   Bacteroides fragilis (strain YCH46).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=295405;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YCH46;
RX   PubMed=15466707; DOI=10.1073/pnas.0404172101;
RA   Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N.,
RA   Kuhara S., Hattori M., Hayashi T., Ohnishi Y.;
RT   "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions
RT   regulating cell surface adaptation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004).
CC   -!- FUNCTION: Catalyzes the dehydration of D-mannonate. {ECO:0000255|HAMAP-
CC       Rule:MF_00106}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O;
CC         Xref=Rhea:RHEA:20097, ChEBI:CHEBI:15377, ChEBI:CHEBI:17767,
CC         ChEBI:CHEBI:57990; EC=4.2.1.8; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00106};
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00106};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00106};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00106}.
CC   -!- SIMILARITY: Belongs to the mannonate dehydratase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00106}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAD46926.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AP006841; BAD46926.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_097460.1; NC_006347.1.
DR   AlphaFoldDB; Q650A0; -.
DR   SMR; Q650A0; -.
DR   STRING; 295405.BF0177; -.
DR   EnsemblBacteria; BAD46926; BAD46926; BF0177.
DR   KEGG; bfr:BF0177; -.
DR   PATRIC; fig|295405.11.peg.209; -.
DR   HOGENOM; CLU_058621_2_0_10; -.
DR   OMA; GIVWALH; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000002197; Chromosome.
DR   GO; GO:0008927; F:mannonate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00106; UxuA; 1.
DR   InterPro; IPR004628; Man_deHydtase.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   PANTHER; PTHR30387; PTHR30387; 1.
DR   Pfam; PF03786; UxuA; 1.
DR   PIRSF; PIRSF016049; Man_dehyd; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR00695; uxuA; 1.
PE   3: Inferred from homology;
KW   Iron; Lyase; Manganese.
FT   CHAIN           1..396
FT                   /note="Mannonate dehydratase"
FT                   /id="PRO_0000231050"
SQ   SEQUENCE   396 AA;  45357 MW;  62667B3582CE084F CRC64;
     MTLLKDKLFL SEQTWRWYGP DDPVSLWDIK QAGATGIVNA LHHIPNGEVW TVEEIMKRKE
     LIESVGLKWS VVESVPVHEH IKTQTGNFRK YIENYKESLR NLGQCGIHIV TYNFMPVLDW
     TRTDLAYTLP DGSKALRFER AAFIAFDLFL LKRPGAETEY TDEEKTKARI RFEQMDEKEK
     QLLVRNMIAG LPGSEESFTL EQFQHELDRY RGIDAEKLRT HLIYFLKEIT STADEAGVKL
     VIHPDDPPCS ILGLPRIMSC AEDFQALIDA VPNESNGLCL CTGSLGVSCA NDLEGMMRRF
     GDRINFVHFR STQRDAEGNF YEANHLEGDV DMYHVMKAFL ELQQRRKVSI PMRPDHGHQM
     VDDLKKKTNP GYSCIGRLRG LAELRGLEMG IAKSIF