ID   UXUA_BACTN              Reviewed;         389 AA.
AC   Q8A7U2;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Mannonate dehydratase {ECO:0000255|HAMAP-Rule:MF_00106};
DE            EC=4.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00106};
DE   AltName: Full=D-mannonate hydro-lyase {ECO:0000255|HAMAP-Rule:MF_00106};
GN   Name=uxuA {ECO:0000255|HAMAP-Rule:MF_00106}; OrderedLocusNames=BT_1432;
OS   Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS   CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=226186;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC   VPI-5482 / E50;
RX   PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA   Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
CC   -!- FUNCTION: Catalyzes the dehydration of D-mannonate. {ECO:0000255|HAMAP-
CC       Rule:MF_00106}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O;
CC         Xref=Rhea:RHEA:20097, ChEBI:CHEBI:15377, ChEBI:CHEBI:17767,
CC         ChEBI:CHEBI:57990; EC=4.2.1.8; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00106};
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00106};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00106};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00106}.
CC   -!- SIMILARITY: Belongs to the mannonate dehydratase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00106}.
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DR   EMBL; AE015928; AAO76539.1; -; Genomic_DNA.
DR   RefSeq; NP_810345.1; NC_004663.1.
DR   RefSeq; WP_011107776.1; NC_004663.1.
DR   AlphaFoldDB; Q8A7U2; -.
DR   SMR; Q8A7U2; -.
DR   STRING; 226186.BT_1432; -.
DR   PaxDb; Q8A7U2; -.
DR   PRIDE; Q8A7U2; -.
DR   EnsemblBacteria; AAO76539; AAO76539; BT_1432.
DR   GeneID; 60927415; -.
DR   KEGG; bth:BT_1432; -.
DR   PATRIC; fig|226186.12.peg.1464; -.
DR   eggNOG; COG1312; Bacteria.
DR   HOGENOM; CLU_058621_2_0_10; -.
DR   InParanoid; Q8A7U2; -.
DR   OMA; GIVWALH; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001414; Chromosome.
DR   GO; GO:0008198; F:ferrous iron binding; IBA:GO_Central.
DR   GO; GO:0030145; F:manganese ion binding; IBA:GO_Central.
DR   GO; GO:0008927; F:mannonate dehydratase activity; IBA:GO_Central.
DR   GO; GO:0042840; P:D-glucuronate catabolic process; IBA:GO_Central.
DR   HAMAP; MF_00106; UxuA; 1.
DR   InterPro; IPR004628; Man_deHydtase.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   PANTHER; PTHR30387; PTHR30387; 1.
DR   Pfam; PF03786; UxuA; 1.
DR   PIRSF; PIRSF016049; Man_dehyd; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR00695; uxuA; 1.
PE   3: Inferred from homology;
KW   Iron; Lyase; Manganese; Reference proteome.
FT   CHAIN           1..389
FT                   /note="Mannonate dehydratase"
FT                   /id="PRO_0000170665"
SQ   SEQUENCE   389 AA;  44460 MW;  49AF971B14104B8E CRC64;
     MYLCEQTWRW YGPNDPVSLW DIKQAGATGI VNALHHIPNG EVWTVEEIMK RKQMIEEVGL
     TWSVVESVPV HEHIKTQTGE YLKYIENYKE SIRNLAKCGV MVVTYNFMPV LDWTRTDLAY
     TMPDGSKALR FEKAAFLAFD LFILKRPNAE KDYTPEEIAK AKARFEQMSE DDKKLLVRNM
     IAGLPGSEES FTVEQFQEAL DRYNDIDAEK LRSNLIFFLK EIAPVADEVG VKLVIHPDDP
     PYTILGLPRI LSTEEDFKKL IEAVPNESNG LCLCTGSFGV RADNDLAGMM ERFGDRVNFV
     HLRSTQRDEE GNFYEANHLE GNVDMYNVMK SLILLQQRRK CSIAMRPDHG HQMIDDLKKK
     TNPGYSCLGR LRGLAELRGL EMGIAKSIL