ID   UXUA_BRUSI              Reviewed;         401 AA.
AC   A9WZA3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Mannonate dehydratase {ECO:0000255|HAMAP-Rule:MF_00106};
DE            EC=4.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00106};
DE   AltName: Full=D-mannonate hydro-lyase {ECO:0000255|HAMAP-Rule:MF_00106};
GN   Name=uxuA {ECO:0000255|HAMAP-Rule:MF_00106}; OrderedLocusNames=BSUIS_B0806;
OS   Brucella suis (strain ATCC 23445 / NCTC 10510).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=470137;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23445 / NCTC 10510;
RA   Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J., Dharmanolla C.,
RA   Gillespie J.J., Kenyon R.W., Lu J., Mane S., Mohapatra S., Nagrani S.,
RA   Purkayastha A., Rajasimha H.K., Shallom J.M., Shallom S., Shukla M.,
RA   Snyder E.E., Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H.,
RA   Bruce D., Detter C., Munk C., Brettin T.S.;
RT   "Brucella suis ATCC 23445 whole genome shotgun sequencing project.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the dehydration of D-mannonate. {ECO:0000255|HAMAP-
CC       Rule:MF_00106}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O;
CC         Xref=Rhea:RHEA:20097, ChEBI:CHEBI:15377, ChEBI:CHEBI:17767,
CC         ChEBI:CHEBI:57990; EC=4.2.1.8; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00106};
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00106};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00106};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00106}.
CC   -!- SIMILARITY: Belongs to the mannonate dehydratase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00106}.
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DR   EMBL; CP000912; ABY39769.1; -; Genomic_DNA.
DR   RefSeq; WP_004690313.1; NC_010167.1.
DR   AlphaFoldDB; A9WZA3; -.
DR   SMR; A9WZA3; -.
DR   EnsemblBacteria; ABY39769; ABY39769; BSUIS_B0806.
DR   GeneID; 45053830; -.
DR   GeneID; 55592464; -.
DR   KEGG; bmt:BSUIS_B0806; -.
DR   HOGENOM; CLU_058621_2_0_5; -.
DR   OMA; AIVKAYH; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000008545; Chromosome II.
DR   GO; GO:0008927; F:mannonate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00106; UxuA; 1.
DR   InterPro; IPR004628; Man_deHydtase.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   PANTHER; PTHR30387; PTHR30387; 1.
DR   Pfam; PF03786; UxuA; 1.
DR   PIRSF; PIRSF016049; Man_dehyd; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR00695; uxuA; 1.
PE   3: Inferred from homology;
KW   Iron; Lyase; Manganese.
FT   CHAIN           1..401
FT                   /note="Mannonate dehydratase"
FT                   /id="PRO_1000075897"
SQ   SEQUENCE   401 AA;  44445 MW;  399192F5F46A0921 CRC64;
     MRQAWRWFGP EAGVPLDAVR QAGATDIVSA LHEVPIGQEW TSAQIVERKN LIESTPTGRH
     PLTWSVVESI PVSDDIKRSG KAARHDIGAW IASMEALARN DIKVICYNFM PVVDWCRTDL
     DYITSTGATA MRFDQDRFAA FDLHILQRKG AEKDYSEEDR IAARAIFEAM DETEIEQLIV
     NIASALPGST TEPLTIPAFR EKLETYASID AAHLRRNLVE FLEAVTPVAD SLGVKLTLHP
     DDPPRSLFGL PRIASTEADY AAIFAAVPAQ SNGMCFCTGS LGVRADNDLP AIARRFASRI
     HFSHLRATTR EGDGRTFHEA AHLEGDVDMV GILRILLEED RKRDAGQTII FRSDHGHRMM
     DDLEKKVTPG YPVIGRMRGL AELRGIITAL DACALEYDPN V