ID   CAH11_SHEEP             Reviewed;         328 AA.
AC   Q95203;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1999, sequence version 2.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Carbonic anhydrase-related protein 11;
DE   AltName: Full=CA-RP XI;
DE            Short=CA-XI;
DE            Short=CARP XI;
DE   AltName: Full=Carbonic anhydrase-related protein 2;
DE            Short=CA-RP II;
DE            Short=CARP-2;
DE   Flags: Precursor;
GN   Name=CA11; Synonyms=CARP2;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=9878252; DOI=10.1006/geno.1998.5585;
RA   Lovejoy D.A., Hewett-Emmett D., Porter C.A., Cepoi D., Sheffield A.,
RA   Vale W.W., Tashian R.E.;
RT   "Evolutionarily conserved, 'acatalytic' carbonic anhydrase-related protein
RT   XI contains a sequence motif present in the neuropeptide sauvagine: the
RT   human CA-RP XI gene (CA11) is embedded between the secretor gene cluster
RT   and the DBP gene at 19q13.3.";
RL   Genomics 54:484-493(1998).
CC   -!- FUNCTION: Does not have a catalytic activity.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
CC       {ECO:0000305}.
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DR   EMBL; Y07785; CAA69107.1; -; mRNA.
DR   RefSeq; NP_001009408.1; NM_001009408.2.
DR   AlphaFoldDB; Q95203; -.
DR   SMR; Q95203; -.
DR   STRING; 9940.ENSOARP00000012872; -.
DR   Ensembl; ENSOART00020026406; ENSOARP00020021912; ENSOARG00020017176.
DR   GeneID; 443426; -.
DR   KEGG; oas:443426; -.
DR   CTD; 770; -.
DR   eggNOG; KOG0382; Eukaryota.
DR   OrthoDB; 1377476at2759; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd03121; alpha_CARP_X_XI_like; 1.
DR   Gene3D; 3.10.200.10; -; 1.
DR   InterPro; IPR041878; Alpha_CARP_X/XI.
DR   InterPro; IPR001148; CA_dom.
DR   InterPro; IPR036398; CA_dom_sf.
DR   InterPro; IPR023561; Carbonic_anhydrase_a-class.
DR   PANTHER; PTHR18952; PTHR18952; 1.
DR   Pfam; PF00194; Carb_anhydrase; 1.
DR   SMART; SM01057; Carb_anhydrase; 1.
DR   SUPFAM; SSF51069; SSF51069; 1.
DR   PROSITE; PS51144; ALPHA_CA_2; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..328
FT                   /note="Carbonic anhydrase-related protein 11"
FT                   /id="PRO_0000004247"
FT   DOMAIN          33..303
FT                   /note="Alpha-carbonic anhydrase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01134"
FT   REGION          300..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        118
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   328 AA;  36199 MW;  E28A6C7236EC41C3 CRC64;
     MGAAPRLSAP RVLVLWAALG AAAHIGPAPD PEDWWSYKDN LQGNFVPGPP FWGLVNAAWS
     LCAVGKRQSP VDVDLKRVLY DPFLPPLRLS TGGEKLRGTL YNTGRHVSFL PAPRPVVNVS
     GGPLLYSHRL SELRLLFGAR DGAGSEHQIN HQGFSAEVQL IHFNQELYGN LSAATRGPNG
     LAILSLFVNV AGSSNPFLSR LLNRDTITRI SYKNDAYFLQ DLSLELLFPE SFGFITYQGS
     LSTPPCSETV TWILIDRALN ITSLQMHSLR LLSQNPPSQI FQSLSGNGRP LQPLAHRALR
     GNRDPRHPER RCRGPNYRLH VDDVPHGL