ID   UXUA_CUPTR              Reviewed;         346 AA.
AC   B3R1A0;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Mannonate dehydratase {ECO:0000255|HAMAP-Rule:MF_00106};
DE            EC=4.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00106};
DE   AltName: Full=D-mannonate hydro-lyase {ECO:0000255|HAMAP-Rule:MF_00106};
GN   Name=uxuA {ECO:0000255|HAMAP-Rule:MF_00106}; OrderedLocusNames=RALTA_A1563;
OS   Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP
OS   107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=977880;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 / R1;
RX   PubMed=18490699; DOI=10.1101/gr.076448.108;
RA   Amadou C., Pascal G., Mangenot S., Glew M., Bontemps C., Capela D.,
RA   Carrere S., Cruveiller S., Dossat C., Lajus A., Marchetti M., Poinsot V.,
RA   Rouy Z., Servin B., Saad M., Schenowitz C., Barbe V., Batut J., Medigue C.,
RA   Masson-Boivin C.;
RT   "Genome sequence of the beta-rhizobium Cupriavidus taiwanensis and
RT   comparative genomics of rhizobia.";
RL   Genome Res. 18:1472-1483(2008).
CC   -!- FUNCTION: Catalyzes the dehydration of D-mannonate. {ECO:0000255|HAMAP-
CC       Rule:MF_00106}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O;
CC         Xref=Rhea:RHEA:20097, ChEBI:CHEBI:15377, ChEBI:CHEBI:17767,
CC         ChEBI:CHEBI:57990; EC=4.2.1.8; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00106};
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00106};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00106};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00106}.
CC   -!- SIMILARITY: Belongs to the mannonate dehydratase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00106}.
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DR   EMBL; CU633749; CAQ69509.1; -; Genomic_DNA.
DR   RefSeq; WP_012352832.1; NC_010528.1.
DR   AlphaFoldDB; B3R1A0; -.
DR   SMR; B3R1A0; -.
DR   STRING; 977880.RALTA_A1563; -.
DR   EnsemblBacteria; CAQ69509; CAQ69509; RALTA_A1563.
DR   GeneID; 29760218; -.
DR   KEGG; cti:RALTA_A1563; -.
DR   eggNOG; COG1312; Bacteria.
DR   HOGENOM; CLU_058621_1_0_4; -.
DR   OMA; AIVKAYH; -.
DR   OrthoDB; 907794at2; -.
DR   BioCyc; CTAI977880:RALTA_RS07500-MON; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001692; Chromosome 1.
DR   GO; GO:0008927; F:mannonate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00106; UxuA; 1.
DR   InterPro; IPR004628; Man_deHydtase.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   PANTHER; PTHR30387; PTHR30387; 1.
DR   Pfam; PF03786; UxuA; 1.
DR   PIRSF; PIRSF016049; Man_dehyd; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR00695; uxuA; 1.
PE   3: Inferred from homology;
KW   Iron; Lyase; Manganese.
FT   CHAIN           1..346
FT                   /note="Mannonate dehydratase"
FT                   /id="PRO_1000094214"
SQ   SEQUENCE   346 AA;  38515 MW;  36C0CCA193D86B63 CRC64;
     MKMSFRWFGP TDPIPLEYIR QIPGMTHIVS AIYDEPVGEV WPLDKIQALK STIEAAGLQF
     KVVESVPVHE DIKLGKPTRE RLIANYQQTI RNLAAAGIEV ICYNFMPVFD WTRTELAKKL
     DDGSTCLAFS TREVEQIDVS QGIALPGWDS SYAHAELQSL LAEYRGIDEG RLWEHLEHFL
     RAIIPVAQEC GIKMAIHPDD PPRPIFGLPR IVKNRDDLAR ILAIVDTPAN GLTLCSGSLG
     AGPQNNVEAL VREFGGMGRI HFAHIRNVKI TPEGDFEETA HLSSCGSLDI AAIVKAYHDV
     GFQGYYRPDH GRMIWGETGK PGYGLYDRAL GAVYINGMWE AMEKTA