ID   UXUA_EDWI9              Reviewed;         396 AA.
AC   C5BG25;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Mannonate dehydratase {ECO:0000255|HAMAP-Rule:MF_00106};
DE            EC=4.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00106};
DE   AltName: Full=D-mannonate hydro-lyase {ECO:0000255|HAMAP-Rule:MF_00106};
GN   Name=uxuA {ECO:0000255|HAMAP-Rule:MF_00106}; OrderedLocusNames=NT01EI_2579;
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146;
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the dehydration of D-mannonate. {ECO:0000255|HAMAP-
CC       Rule:MF_00106}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O;
CC         Xref=Rhea:RHEA:20097, ChEBI:CHEBI:15377, ChEBI:CHEBI:17767,
CC         ChEBI:CHEBI:57990; EC=4.2.1.8; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00106};
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00106};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00106};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00106}.
CC   -!- SIMILARITY: Belongs to the mannonate dehydratase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00106}.
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DR   EMBL; CP001600; ACR69748.1; -; Genomic_DNA.
DR   RefSeq; WP_015871857.1; NC_012779.2.
DR   AlphaFoldDB; C5BG25; -.
DR   SMR; C5BG25; -.
DR   STRING; 67780.B6E78_04950; -.
DR   EnsemblBacteria; ACR69748; ACR69748; NT01EI_2579.
DR   GeneID; 7961767; -.
DR   KEGG; eic:NT01EI_2579; -.
DR   PATRIC; fig|634503.3.peg.2296; -.
DR   HOGENOM; CLU_058621_2_0_6; -.
DR   OMA; GIVWALH; -.
DR   OrthoDB; 907794at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0008927; F:mannonate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00106; UxuA; 1.
DR   InterPro; IPR004628; Man_deHydtase.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   PANTHER; PTHR30387; PTHR30387; 1.
DR   Pfam; PF03786; UxuA; 1.
DR   PIRSF; PIRSF016049; Man_dehyd; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR00695; uxuA; 1.
PE   3: Inferred from homology;
KW   Iron; Lyase; Manganese; Reference proteome.
FT   CHAIN           1..396
FT                   /note="Mannonate dehydratase"
FT                   /id="PRO_1000202869"
SQ   SEQUENCE   396 AA;  44590 MW;  E15DFEAAEEB5869D CRC64;
     MEQTWRWYGP NDPVSLDDVR QAGATGVVTA LHHIPNGEVW SVEEIEKRKA LLAEKGLTWS
     VVESVPVHEE IKTQTGNYQR HIDNYKQSLR NLAACGIDTV CYNFMPVLDW TRTDLEFQLP
     DGSKALRFDQ IAFAAFELHI LKRPGAAEDY SAEEQTQAKS YFDAMGEAEV TKLTANIIAG
     LPGAEEGYTL DQFRARLAEY DGIDKATLRE HMAHFLREIV PVAEACGLRL AVHPDDPPRP
     ILGLPRIVST VEDMQWLKEV VDSVYNGFTM CTGSYGVRAD NDLVAMIERF GDRIHFTHLR
     ATCREANPKS FHEGAHLQGD VDMFAVVKAI LTEESRRQQA GDMRLIPMRP DHGHQMLDDL
     KKKTNPGYSA IGRLKGLAEV RGVELAIKRV YFPQMK