ID   UXUA_MOOTA              Reviewed;         359 AA.
AC   Q2RLC8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Mannonate dehydratase {ECO:0000255|HAMAP-Rule:MF_00106};
DE            EC=4.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00106};
DE   AltName: Full=D-mannonate hydro-lyase {ECO:0000255|HAMAP-Rule:MF_00106};
GN   Name=uxuA {ECO:0000255|HAMAP-Rule:MF_00106}; OrderedLocusNames=Moth_0430;
OS   Moorella thermoacetica (strain ATCC 39073 / JCM 9320).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Moorella group; Moorella.
OX   NCBI_TaxID=264732;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39073 / JCM 9320;
RX   PubMed=18631365; DOI=10.1111/j.1462-2920.2008.01679.x;
RA   Pierce E., Xie G., Barabote R.D., Saunders E., Han C.S., Detter J.C.,
RA   Richardson P., Brettin T.S., Das A., Ljungdahl L.G., Ragsdale S.W.;
RT   "The complete genome sequence of Moorella thermoacetica (f. Clostridium
RT   thermoaceticum).";
RL   Environ. Microbiol. 10:2550-2573(2008).
CC   -!- FUNCTION: Catalyzes the dehydration of D-mannonate. {ECO:0000255|HAMAP-
CC       Rule:MF_00106}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O;
CC         Xref=Rhea:RHEA:20097, ChEBI:CHEBI:15377, ChEBI:CHEBI:17767,
CC         ChEBI:CHEBI:57990; EC=4.2.1.8; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00106};
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00106};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00106};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00106}.
CC   -!- SIMILARITY: Belongs to the mannonate dehydratase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00106}.
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DR   EMBL; CP000232; ABC18761.1; -; Genomic_DNA.
DR   RefSeq; WP_011391968.1; NC_007644.1.
DR   RefSeq; YP_429304.1; NC_007644.1.
DR   AlphaFoldDB; Q2RLC8; -.
DR   SMR; Q2RLC8; -.
DR   STRING; 264732.Moth_0430; -.
DR   EnsemblBacteria; ABC18761; ABC18761; Moth_0430.
DR   KEGG; mta:Moth_0430; -.
DR   PATRIC; fig|264732.11.peg.464; -.
DR   eggNOG; COG1312; Bacteria.
DR   HOGENOM; CLU_058621_1_0_9; -.
DR   OMA; GIVWALH; -.
DR   UniPathway; UPA00246; -.
DR   GO; GO:0008927; F:mannonate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00106; UxuA; 1.
DR   InterPro; IPR004628; Man_deHydtase.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   PANTHER; PTHR30387; PTHR30387; 1.
DR   Pfam; PF03786; UxuA; 1.
DR   PIRSF; PIRSF016049; Man_dehyd; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR00695; uxuA; 2.
PE   3: Inferred from homology;
KW   Iron; Lyase; Manganese.
FT   CHAIN           1..359
FT                   /note="Mannonate dehydratase"
FT                   /id="PRO_1000034334"
SQ   SEQUENCE   359 AA;  40902 MW;  F25F62ECDC20C490 CRC64;
     MKMTFRWFGE GYDSISLDKI RQIPGKPGIV SAIYDVPVGE VWPEEKIKKL KETVENAGLE
     LEVIESVNVH EDIKLGLPSR DRYIENYQQT LRNLAKFGIK VVCYNFMPIF DWTRSDLAKV
     LPDGSTALSY EEEKVQKVDP NRMVEEVEAN SNGFELPGWE PERLKTLKVL FEQYKSVDEE
     KLLKNLGYFL RAIIPVAEEV DIKMAIHPDD PPWSIFGLPR IVKSKESLEK IMALVDSPYN
     GITLCSGSLG ANPDNDIPAL IRYFGAKGRI HFGHVRNIKI HSLRNFDESS HLSSDGSLDM
     FEIMKAYHDI DFKGYIRPDH GRMIWGEVGR PGYGLYDRAL GIAYLNGLWE AIGKMKKVC