ID   UXUA_PHOLL              Reviewed;         395 AA.
AC   Q7N9Y1;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Mannonate dehydratase {ECO:0000255|HAMAP-Rule:MF_00106};
DE            EC=4.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00106};
DE   AltName: Full=D-mannonate hydro-lyase {ECO:0000255|HAMAP-Rule:MF_00106};
GN   Name=uxuA {ECO:0000255|HAMAP-Rule:MF_00106}; OrderedLocusNames=plu0170;
OS   Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS   TT01).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Photorhabdus.
OX   NCBI_TaxID=243265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15139 / CIP 105565 / TT01;
RX   PubMed=14528314; DOI=10.1038/nbt886;
RA   Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA   Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA   Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA   Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA   Glaser P., Boemare N., Danchin A., Kunst F.;
RT   "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT   luminescens.";
RL   Nat. Biotechnol. 21:1307-1313(2003).
CC   -!- FUNCTION: Catalyzes the dehydration of D-mannonate. {ECO:0000255|HAMAP-
CC       Rule:MF_00106}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O;
CC         Xref=Rhea:RHEA:20097, ChEBI:CHEBI:15377, ChEBI:CHEBI:17767,
CC         ChEBI:CHEBI:57990; EC=4.2.1.8; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00106};
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00106};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00106};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00106}.
CC   -!- SIMILARITY: Belongs to the mannonate dehydratase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00106}.
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DR   EMBL; BX571859; CAE12465.1; -; Genomic_DNA.
DR   RefSeq; WP_011144572.1; NC_005126.1.
DR   AlphaFoldDB; Q7N9Y1; -.
DR   SMR; Q7N9Y1; -.
DR   STRING; 243265.plu0170; -.
DR   EnsemblBacteria; CAE12465; CAE12465; plu0170.
DR   GeneID; 24168479; -.
DR   KEGG; plu:plu0170; -.
DR   eggNOG; COG1312; Bacteria.
DR   HOGENOM; CLU_058621_2_0_6; -.
DR   OMA; GIVWALH; -.
DR   OrthoDB; 907794at2; -.
DR   BioCyc; PLUM243265:PLU_RS00825-MON; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000002514; Chromosome.
DR   GO; GO:0008927; F:mannonate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00106; UxuA; 1.
DR   InterPro; IPR004628; Man_deHydtase.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   PANTHER; PTHR30387; PTHR30387; 1.
DR   Pfam; PF03786; UxuA; 1.
DR   PIRSF; PIRSF016049; Man_dehyd; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR00695; uxuA; 1.
PE   3: Inferred from homology;
KW   Iron; Lyase; Manganese; Reference proteome.
FT   CHAIN           1..395
FT                   /note="Mannonate dehydratase"
FT                   /id="PRO_0000170679"
SQ   SEQUENCE   395 AA;  45317 MW;  7D7FBFE685E8559D CRC64;
     MEQTWRWFGP NDPVSLDDIR QAGATGIVTA LHHIPNGHIW NKDEILARKT LIENKGLIWS
     VVESVPVHEE IKTRTGHYSQ WINNYKTSLK NLAECGIDTV CYNFMPVLDW TRTDLEYSLP
     DGSKALRFDQ IAFAAFEIYI LKRPNAEADY TVEEQAQAKV YHDNMSAADI KKLTTNIIAG
     LPGAEEGYTL AEFQAQLDRY KDITRDKLRE HLAYFLHQIV PVCEEYGLRL AIHPDDPPRP
     ILGLPRIIST IEDIEWLTTI EPSPANGITM CTGSYGVRSD NDLVEIIKHY GNRIYFTHLR
     STQREENSKT FHEATHLAGD VDMYNVVMEI LREEYRRKKV GDNRLIPMRP DHGHQIIDDL
     KKQTNPGYSC IGRLKGLAEI RGLELGLRRA FFENK