ID   UXUA_SALTY              Reviewed;         394 AA.
AC   P0A2M7; P43668;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Mannonate dehydratase;
DE            EC=4.2.1.8;
DE   AltName: Full=D-mannonate hydro-lyase;
GN   Name=uxuA; OrderedLocusNames=STM3135;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-50.
RC   STRAIN=ATCC 14028 / Isolates MS1633/MS6290;
RX   PubMed=8168923; DOI=10.1128/iai.62.5.1623-1630.1994;
RA   Baumler A.J., Kusters J.G., Stojiljkovic I., Heffron F.;
RT   "Salmonella typhimurium loci involved in survival within macrophages.";
RL   Infect. Immun. 62:1623-1630(1994).
RN   [3]
RP   IDENTIFICATION.
RA   Rudd K.E.;
RL   Unpublished observations (JUL-1995).
CC   -!- FUNCTION: Catalyzes the dehydration of D-mannonate. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O;
CC         Xref=Rhea:RHEA:20097, ChEBI:CHEBI:15377, ChEBI:CHEBI:17767,
CC         ChEBI:CHEBI:57990; EC=4.2.1.8;
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000250};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion.
CC   -!- SIMILARITY: Belongs to the mannonate dehydratase family. {ECO:0000305}.
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DR   EMBL; AE006468; AAL22009.1; -; Genomic_DNA.
DR   EMBL; U06130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; U06140; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_462050.1; NC_003197.2.
DR   RefSeq; WP_000815487.1; NC_003197.2.
DR   AlphaFoldDB; P0A2M7; -.
DR   SMR; P0A2M7; -.
DR   STRING; 99287.STM3135; -.
DR   PaxDb; P0A2M7; -.
DR   EnsemblBacteria; AAL22009; AAL22009; STM3135.
DR   GeneID; 1254658; -.
DR   KEGG; stm:STM3135; -.
DR   PATRIC; fig|99287.12.peg.3323; -.
DR   HOGENOM; CLU_058621_2_0_6; -.
DR   OMA; GIVWALH; -.
DR   PhylomeDB; P0A2M7; -.
DR   BioCyc; SENT99287:STM3135-MON; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0008198; F:ferrous iron binding; IBA:GO_Central.
DR   GO; GO:0030145; F:manganese ion binding; IBA:GO_Central.
DR   GO; GO:0008927; F:mannonate dehydratase activity; IBA:GO_Central.
DR   GO; GO:0042840; P:D-glucuronate catabolic process; IBA:GO_Central.
DR   HAMAP; MF_00106; UxuA; 1.
DR   InterPro; IPR004628; Man_deHydtase.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   PANTHER; PTHR30387; PTHR30387; 1.
DR   Pfam; PF03786; UxuA; 1.
DR   PIRSF; PIRSF016049; Man_dehyd; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR00695; uxuA; 1.
PE   3: Inferred from homology;
KW   Iron; Lyase; Manganese; Reference proteome.
FT   CHAIN           1..394
FT                   /note="Mannonate dehydratase"
FT                   /id="PRO_0000170685"
FT   CONFLICT        23
FT                   /note="G -> A (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        43..44
FT                   /note="DE -> AK (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   394 AA;  44937 MW;  CA690041E17D119F CRC64;
     MKQTWRWYGP NDPVTLSDVR QAGATGVVTA LHHIPNGEIW SVDEIQKRKA IVEEAGLEWS
     VVESVPIHED IKTHTGQYDL WIKNYQQTLR NLAQCGIYTV CYNFMPVLDW TRTDLEYVLP
     DGSKALRFDQ IEFAAFELHI LKRPGAEADY TAEEIAQAER RFATMSEEDK ARLTRNIIAG
     LPGAEEGYTL DQFRQHLATY KDIDKAKLRE HFAYFLKAII PVADEVGVRM AVHPDDPPRP
     ILGLPRIVST IEDMQWMVET VNSMANGFTM CTGSYGVRAD NDLVDMIKQF GPRIYFTHLR
     STLREENPKT FHEAAHLHGD VDMYEVVKAI VEEEHRRKAE GSDDLIPMRP DHGHQMLDDL
     KKKTNPGYSA IGRLKGLAEV RGVELAIQRA FFSK