UXUA_STRSY
ID UXUA_STRSY Reviewed; 366 AA.
AC A4VVI4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=Mannonate dehydratase {ECO:0000255|HAMAP-Rule:MF_00106};
DE EC=4.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00106};
DE AltName: Full=D-mannonate hydro-lyase {ECO:0000255|HAMAP-Rule:MF_00106};
GN Name=uxuA {ECO:0000255|HAMAP-Rule:MF_00106}; OrderedLocusNames=SSU05_1157;
OS Streptococcus suis (strain 05ZYH33).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=391295;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05ZYH33;
RX PubMed=17375201; DOI=10.1371/journal.pone.0000315;
RA Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X.,
RA Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J.,
RA Dong Y., Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F.,
RA Yang R., Wang J., Yu J.;
RT "A glimpse of streptococcal toxic shock syndrome from comparative genomics
RT of S. suis 2 Chinese isolates.";
RL PLoS ONE 2:E315-E315(2007).
CC -!- FUNCTION: Catalyzes the dehydration of D-mannonate. {ECO:0000255|HAMAP-
CC Rule:MF_00106}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O;
CC Xref=Rhea:RHEA:20097, ChEBI:CHEBI:15377, ChEBI:CHEBI:17767,
CC ChEBI:CHEBI:57990; EC=4.2.1.8; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00106};
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00106};
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00106};
CC -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC interconversion. {ECO:0000255|HAMAP-Rule:MF_00106}.
CC -!- SIMILARITY: Belongs to the mannonate dehydratase family.
CC {ECO:0000255|HAMAP-Rule:MF_00106}.
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DR EMBL; CP000407; ABP90123.1; -; Genomic_DNA.
DR PDB; 3BAN; X-ray; 2.90 A; A/B=1-366.
DR PDB; 3BDK; X-ray; 2.50 A; A/B=1-366.
DR PDB; 3DBN; X-ray; 2.90 A; A/B=1-366.
DR PDB; 3FVM; X-ray; 2.90 A; A/B=1-366.
DR PDBsum; 3BAN; -.
DR PDBsum; 3BDK; -.
DR PDBsum; 3DBN; -.
DR PDBsum; 3FVM; -.
DR AlphaFoldDB; A4VVI4; -.
DR SMR; A4VVI4; -.
DR STRING; 391295.SSU05_1157; -.
DR EnsemblBacteria; ABP90123; ABP90123; SSU05_1157.
DR KEGG; ssu:SSU05_1157; -.
DR eggNOG; COG1312; Bacteria.
DR HOGENOM; CLU_058621_1_0_9; -.
DR OMA; AIVKAYH; -.
DR BRENDA; 4.2.1.8; 7186.
DR UniPathway; UPA00246; -.
DR EvolutionaryTrace; A4VVI4; -.
DR Proteomes; UP000000243; Chromosome.
DR GO; GO:0008927; F:mannonate dehydratase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR HAMAP; MF_00106; UxuA; 1.
DR InterPro; IPR004628; Man_deHydtase.
DR InterPro; IPR036237; Xyl_isomerase-like_sf.
DR PANTHER; PTHR30387; PTHR30387; 1.
DR Pfam; PF03786; UxuA; 1.
DR PIRSF; PIRSF016049; Man_dehyd; 1.
DR SUPFAM; SSF51658; SSF51658; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Iron; Lyase; Manganese; Reference proteome.
FT CHAIN 1..366
FT /note="Mannonate dehydratase"
FT /id="PRO_1000034339"
FT STRAND 4..6
FT /evidence="ECO:0007829|PDB:3BAN"
FT HELIX 16..20
FT /evidence="ECO:0007829|PDB:3BDK"
FT STRAND 27..30
FT /evidence="ECO:0007829|PDB:3BDK"
FT STRAND 37..39
FT /evidence="ECO:0007829|PDB:3BDK"
FT HELIX 43..54
FT /evidence="ECO:0007829|PDB:3BDK"
FT TURN 55..57
FT /evidence="ECO:0007829|PDB:3BDK"
FT STRAND 59..64
FT /evidence="ECO:0007829|PDB:3BDK"
FT HELIX 70..73
FT /evidence="ECO:0007829|PDB:3BDK"
FT HELIX 79..94
FT /evidence="ECO:0007829|PDB:3BDK"
FT TURN 95..97
FT /evidence="ECO:0007829|PDB:3BDK"
FT STRAND 100..103
FT /evidence="ECO:0007829|PDB:3BDK"
FT STRAND 114..119
FT /evidence="ECO:0007829|PDB:3BDK"
FT STRAND 125..130
FT /evidence="ECO:0007829|PDB:3BDK"
FT HELIX 131..134
FT /evidence="ECO:0007829|PDB:3BDK"
FT HELIX 156..167
FT /evidence="ECO:0007829|PDB:3BDK"
FT HELIX 171..190
FT /evidence="ECO:0007829|PDB:3BDK"
FT STRAND 191..193
FT /evidence="ECO:0007829|PDB:3BDK"
FT STRAND 195..198
FT /evidence="ECO:0007829|PDB:3BDK"
FT STRAND 202..205
FT /evidence="ECO:0007829|PDB:3BDK"
FT HELIX 217..225
FT /evidence="ECO:0007829|PDB:3BDK"
FT STRAND 232..237
FT /evidence="ECO:0007829|PDB:3BDK"
FT HELIX 238..242
FT /evidence="ECO:0007829|PDB:3BDK"
FT HELIX 249..258
FT /evidence="ECO:0007829|PDB:3BDK"
FT STRAND 262..266
FT /evidence="ECO:0007829|PDB:3BDK"
FT STRAND 270..273
FT /evidence="ECO:0007829|PDB:3BDK"
FT STRAND 276..279
FT /evidence="ECO:0007829|PDB:3BDK"
FT HELIX 284..286
FT /evidence="ECO:0007829|PDB:3BDK"
FT STRAND 287..289
FT /evidence="ECO:0007829|PDB:3BAN"
FT HELIX 291..300
FT /evidence="ECO:0007829|PDB:3BDK"
FT STRAND 305..308
FT /evidence="ECO:0007829|PDB:3DBN"
FT HELIX 328..348
FT /evidence="ECO:0007829|PDB:3BDK"
SQ SEQUENCE 366 AA; 40808 MW; 9B3C03219A117886 CRC64;
MKMSFRWYGK KDPVTLEEIK AIPGMQGIVT AVYDVPVGQA WPLENILELK KMVEEAGLEI
TVIESIPVHE DIKQGKPNRD ALIENYKTSI RNVGAAGIPV VCYNFMPVFD WTRSDLHHPL
PDGSTSLAFL KSDLAGVDPV ADDLNLPGWD SSYSKEEMKA IIENYRQNIS EEDLWANLEY
FIKAILPTAE EAGVKMAIHP DDPPYGIFGL PRIITGQEAV ERFLNLYDSE HNGITMCVGS
YASDPKNDVL AMTEYALKRN RINFMHTRNV TAGAWGFQET AHLSQAGDID MNAVVKLLVD
YDWQGSLRPD HGRRIWGDQT KTPGYGLYDR ALGATYFNGL YEANMRAAGK TPDFGIKAKT
VGTKEG
