ID   UXUA_VIBVU              Reviewed;         395 AA.
AC   Q8D562;
DT   11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Mannonate dehydratase {ECO:0000255|HAMAP-Rule:MF_00106};
DE            EC=4.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00106};
DE   AltName: Full=D-mannonate hydro-lyase {ECO:0000255|HAMAP-Rule:MF_00106};
GN   Name=uxuA {ECO:0000255|HAMAP-Rule:MF_00106}; OrderedLocusNames=VV2_1064;
OS   Vibrio vulnificus (strain CMCP6).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=216895;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CMCP6;
RA   Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.;
RT   "Complete genome sequence of Vibrio vulnificus CMCP6.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the dehydration of D-mannonate. {ECO:0000255|HAMAP-
CC       Rule:MF_00106}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O;
CC         Xref=Rhea:RHEA:20097, ChEBI:CHEBI:15377, ChEBI:CHEBI:17767,
CC         ChEBI:CHEBI:57990; EC=4.2.1.8; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00106};
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00106};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00106};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00106}.
CC   -!- SIMILARITY: Belongs to the mannonate dehydratase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00106}.
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DR   EMBL; AE016796; AAO07971.1; -; Genomic_DNA.
DR   RefSeq; WP_011081966.1; NC_004460.2.
DR   AlphaFoldDB; Q8D562; -.
DR   SMR; Q8D562; -.
DR   EnsemblBacteria; AAO07971; AAO07971; VV2_1064.
DR   KEGG; vvu:VV2_1064; -.
DR   HOGENOM; CLU_058621_2_0_6; -.
DR   OMA; GIVWALH; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000002275; Chromosome 2.
DR   GO; GO:0008927; F:mannonate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00106; UxuA; 1.
DR   InterPro; IPR004628; Man_deHydtase.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   PANTHER; PTHR30387; PTHR30387; 1.
DR   Pfam; PF03786; UxuA; 1.
DR   PIRSF; PIRSF016049; Man_dehyd; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR00695; uxuA; 1.
PE   3: Inferred from homology;
KW   Iron; Lyase; Manganese.
FT   CHAIN           1..395
FT                   /note="Mannonate dehydratase"
FT                   /id="PRO_0000170692"
SQ   SEQUENCE   395 AA;  44956 MW;  6A7DA81FC18385F4 CRC64;
     MEQTWRWYGP NDPVSLDDIR QAGATGIVNA LHHIPNGEVW SKEEILKRKA IIEAKGLTWS
     VVESVPVHEE IKTQTGNFQQ WIDNYKQTLR NLAECGIDTV CYNFMPVLDW TRTDLEFEMP
     DGSKALRFDQ IAFAAFELHI LKRPGAEADY TEAEQAQALE YFNNMSEAQI QQLTSNIIAG
     LPGAEEGYTL EEFQAQLDRY AGISKDKLRE HMAYFLSQLM PVCEAHGLKL AVHPDDPPRP
     ILGLPRIVST IEDIDWLTEK VPSKMNGLTM CTGSYGVRGD NDLVKMIKKH GERIYFTHLR
     STKREESNPM TFHEAAHLDG DVDMYNVVMA ILDEEQRRAE VGDHRLIPMR PDHGHQMLDD
     LKKKTNPGYS AIGRLKGLAE VRGLEMALKR AFYTK