ID   UXUA_VIBVY              Reviewed;         395 AA.
AC   Q7MBZ9;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2004, sequence version 2.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Mannonate dehydratase {ECO:0000255|HAMAP-Rule:MF_00106};
DE            EC=4.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00106};
DE   AltName: Full=D-mannonate hydro-lyase {ECO:0000255|HAMAP-Rule:MF_00106};
GN   Name=uxuA {ECO:0000255|HAMAP-Rule:MF_00106}; OrderedLocusNames=VVA1588;
OS   Vibrio vulnificus (strain YJ016).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=196600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJ016;
RX   PubMed=14656965; DOI=10.1101/gr.1295503;
RA   Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L.,
RA   Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P.,
RA   Lee C.-T., Hor L.-I., Tsai S.-F.;
RT   "Comparative genome analysis of Vibrio vulnificus, a marine pathogen.";
RL   Genome Res. 13:2577-2587(2003).
CC   -!- FUNCTION: Catalyzes the dehydration of D-mannonate. {ECO:0000255|HAMAP-
CC       Rule:MF_00106}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O;
CC         Xref=Rhea:RHEA:20097, ChEBI:CHEBI:15377, ChEBI:CHEBI:17767,
CC         ChEBI:CHEBI:57990; EC=4.2.1.8; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00106};
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00106};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00106};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00106}.
CC   -!- SIMILARITY: Belongs to the mannonate dehydratase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00106}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC97614.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000038; BAC97614.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_043877613.1; NC_005140.1.
DR   AlphaFoldDB; Q7MBZ9; -.
DR   SMR; Q7MBZ9; -.
DR   STRING; 672.VV93_v1c44580; -.
DR   EnsemblBacteria; BAC97614; BAC97614; BAC97614.
DR   KEGG; vvy:VVA1588; -.
DR   PATRIC; fig|196600.6.peg.4718; -.
DR   eggNOG; COG1312; Bacteria.
DR   HOGENOM; CLU_058621_2_0_6; -.
DR   OMA; GIVWALH; -.
DR   OrthoDB; 907794at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000002675; Chromosome II.
DR   GO; GO:0008927; F:mannonate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   HAMAP; MF_00106; UxuA; 1.
DR   InterPro; IPR004628; Man_deHydtase.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   PANTHER; PTHR30387; PTHR30387; 1.
DR   Pfam; PF03786; UxuA; 1.
DR   PIRSF; PIRSF016049; Man_dehyd; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR00695; uxuA; 1.
PE   3: Inferred from homology;
KW   Iron; Lyase; Manganese; Reference proteome.
FT   CHAIN           1..395
FT                   /note="Mannonate dehydratase"
FT                   /id="PRO_0000170693"
SQ   SEQUENCE   395 AA;  44947 MW;  E144A3DD6DE67727 CRC64;
     MEQTWRWYGP NDPVSLDDIC QAGATGIVNA LHHIPNGEVW SKEEILKRKA IIEEKGLTWS
     VVESVPVHEE IKTQTGNFQQ WIDNYKQTLR NLAECGIDTV CYNFMPVLDW TRTDLEFEMP
     DGSKALRFDQ IAFAAFELHI LKRPGAEADY SEAEQAQALE YFNNMSEAQI QQLTSNIIAG
     LPGAEEGYTL EEFQAQLDRY AGISKDKLRE HMAYFLSQLM PVCEAHGLKL AVHPDDPPRP
     ILGLPRIVST IEDIDWLTEK VPSKMNGLTM CTGSYGVRGD NDLVKMIKKH GERIYFTHLR
     STKREESNPM TFHEAAHLDG DVDMYNVVMA ILDEEQRRAE VGDHRLIPMR PDHGHQMLDD
     LKKKTNPGYS AIGRLKGLAE VRGLEMALKR AFYTK