ID   UXUR_ECOLI              Reviewed;         257 AA.
AC   P39161; Q2M5Y9;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=Uxu operon transcriptional regulator;
GN   Name=uxuR; OrderedLocusNames=b4324, JW4287;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RA   Mizobuchi K.;
RL   Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA   Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT   "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT   from 92.8 through 100 minutes.";
RL   Nucleic Acids Res. 23:2105-2119(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: Repressor for the uxuRBA operon.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D13329; BAA02592.1; -; Genomic_DNA.
DR   EMBL; U14003; AAA97220.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC77280.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE78317.1; -; Genomic_DNA.
DR   PIR; S56549; S56549.
DR   RefSeq; NP_418744.1; NC_000913.3.
DR   RefSeq; WP_000833679.1; NZ_SSUV01000012.1.
DR   AlphaFoldDB; P39161; -.
DR   SMR; P39161; -.
DR   BioGRID; 4261007; 10.
DR   DIP; DIP-11110N; -.
DR   IntAct; P39161; 2.
DR   STRING; 511145.b4324; -.
DR   jPOST; P39161; -.
DR   PaxDb; P39161; -.
DR   PRIDE; P39161; -.
DR   EnsemblBacteria; AAC77280; AAC77280; b4324.
DR   EnsemblBacteria; BAE78317; BAE78317; BAE78317.
DR   GeneID; 948849; -.
DR   KEGG; ecj:JW4287; -.
DR   KEGG; eco:b4324; -.
DR   PATRIC; fig|511145.12.peg.4466; -.
DR   EchoBASE; EB4151; -.
DR   eggNOG; COG2186; Bacteria.
DR   HOGENOM; CLU_017584_9_5_6; -.
DR   InParanoid; P39161; -.
DR   OMA; EDFHRTI; -.
DR   PhylomeDB; P39161; -.
DR   BioCyc; EcoCyc:EG20249-MON; -.
DR   PRO; PR:P39161; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEP:EcoCyc.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   InterPro; IPR011711; GntR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF07729; FCD; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00895; FCD; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   4: Predicted;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..257
FT                   /note="Uxu operon transcriptional regulator"
FT                   /id="PRO_0000050670"
FT   DOMAIN          8..76
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        36..55
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   257 AA;  29308 MW;  FA9A64922E5F5F5A CRC64;
     MKSATSAQRP YQEVGAMIRD LIIKTPYNPG ERLPPEREIA EMLDVTRTVV REALIMLEIK
     GLVEVRRGAG IYVLDNSGSQ NTDSPDANVC NDAGPFELLQ ARQLLESNIA EFAALQATRE
     DIVKMRQALQ LEERELASSA PGSSESGDMQ FHLAIAEATH NSMLVELFRQ SWQWRENNPM
     WIQLHSHLDD SLYRKEWLGD HKQILAALIK KDARAAKLAM WQHLENVKQR LLEFSNVDDI
     YFDGYLFDSW PLDKVDA