ID   UXUR_HAEIN              Reviewed;         266 AA.
AC   P44487;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Uxu operon regulator;
GN   Name=uxuR; OrderedLocusNames=HI_0054;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Repressor for the uxuRBA operon. {ECO:0000250}.
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DR   EMBL; L42023; AAC21732.1; -; Genomic_DNA.
DR   PIR; D64045; D64045.
DR   RefSeq; NP_438227.2; NC_000907.1.
DR   AlphaFoldDB; P44487; -.
DR   SMR; P44487; -.
DR   STRING; 71421.HI_0054; -.
DR   EnsemblBacteria; AAC21732; AAC21732; HI_0054.
DR   KEGG; hin:HI_0054; -.
DR   PATRIC; fig|71421.8.peg.54; -.
DR   eggNOG; COG2186; Bacteria.
DR   HOGENOM; CLU_017584_9_5_6; -.
DR   OMA; SAQMRQH; -.
DR   PhylomeDB; P44487; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   InterPro; IPR011711; GntR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF07729; FCD; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00895; FCD; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..266
FT                   /note="Uxu operon regulator"
FT                   /id="PRO_0000050671"
FT   DOMAIN          23..91
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        51..70
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   266 AA;  30919 MW;  B54E86EBA120CDC0 CRC64;
     MSHITKIKNW NTNLRKNMEN IVNRTYTRIG QLLKQDISQG IYSIGDKLPT EREISEKFGV
     SRTIVREAMV MLEVEKLVEV KKGSGVYVVR TPESIHMEHS DLPDVGPFEL LQARQLLESS
     IAEFAALQAT KKDILNLKQI LNREKELLTQ NQDDYSADKD FHLALAEITQ NDVLVKLQEQ
     LWQYRFNSAM WAQLHSRILQ NDYHHLWIED HQTILSAIQK KNANEARKAM WQHLENVKVK
     LFELSDVEDP HFDGYLFNTN PVVVGI