UZIP_DROME
ID UZIP_DROME Reviewed; 488 AA.
AC P10379; Q960B4; Q9W0W7;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2003, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Protein unzipped;
DE AltName: Full=Protein zipper;
DE Flags: Precursor;
GN Name=uzip; Synonyms=zip; ORFNames=CG3533;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3402433; DOI=10.1002/j.1460-2075.1988.tb02920.x;
RA Zhao D.-B., Code S., Jaehnig F., Haller J., Jaeckle H.;
RT "Zipper encodes a putative integral membrane protein required for normal
RT axon patterning during Drosophila neurogenesis.";
RL EMBO J. 7:1115-1119(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-232, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=Oregon-R; TISSUE=Head;
RX PubMed=17893096; DOI=10.1093/glycob/cwm097;
RA Koles K., Lim J.-M., Aoki K., Porterfield M., Tiemeyer M., Wells L.,
RA Panin V.;
RT "Identification of N-glycosylated proteins from the central nervous system
RT of Drosophila melanogaster.";
RL Glycobiology 17:1388-1403(2007).
RN [6]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-232, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=19349973; DOI=10.1038/nbt.1532;
RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
RA Schiess R., Aebersold R., Watts J.D.;
RT "Mass-spectrometric identification and relative quantification of N-linked
RT cell surface glycoproteins.";
RL Nat. Biotechnol. 27:378-386(2009).
CC -!- FUNCTION: Required for normal axon patterning during neurogenesis.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
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DR EMBL; X07450; CAA30332.1; -; mRNA.
DR EMBL; AE013599; AAF47312.2; -; Genomic_DNA.
DR EMBL; AY052139; AAK93563.1; -; mRNA.
DR PIR; S00483; EPFF.
DR RefSeq; NP_001286875.1; NM_001299946.1.
DR RefSeq; NP_523861.1; NM_079137.3.
DR AlphaFoldDB; P10379; -.
DR SMR; P10379; -.
DR BioGRID; 63570; 9.
DR DIP; DIP-18057N; -.
DR IntAct; P10379; 6.
DR STRING; 7227.FBpp0072304; -.
DR GlyGen; P10379; 5 sites.
DR iPTMnet; P10379; -.
DR PaxDb; P10379; -.
DR PRIDE; P10379; -.
DR DNASU; 38002; -.
DR EnsemblMetazoa; FBtr0072397; FBpp0072304; FBgn0004055.
DR EnsemblMetazoa; FBtr0345678; FBpp0311729; FBgn0004055.
DR GeneID; 38002; -.
DR KEGG; dme:Dmel_CG3533; -.
DR UCSC; CG3533-RA; d. melanogaster.
DR CTD; 38002; -.
DR FlyBase; FBgn0004055; uzip.
DR VEuPathDB; VectorBase:FBgn0004055; -.
DR eggNOG; ENOG502RY58; Eukaryota.
DR HOGENOM; CLU_037895_1_0_1; -.
DR InParanoid; P10379; -.
DR OMA; AFYYGSD; -.
DR OrthoDB; 831655at2759; -.
DR PhylomeDB; P10379; -.
DR BioGRID-ORCS; 38002; 0 hits in 1 CRISPR screen.
DR ChiTaRS; uzip; fly.
DR GenomeRNAi; 38002; -.
DR PRO; PR:P10379; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0004055; Expressed in second segment of antenna (Drosophila) and 42 other tissues.
DR ExpressionAtlas; P10379; baseline and differential.
DR Genevisible; P10379; DM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; HDA:FlyBase.
DR GO; GO:0007411; P:axon guidance; IMP:FlyBase.
DR GO; GO:0007413; P:axonal fasciculation; IMP:FlyBase.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; Glycoprotein; Membrane;
KW Neurogenesis; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..488
FT /note="Protein unzipped"
FT /id="PRO_0000022645"
FT TOPO_DOM 22..465
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 466..486
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 487..488
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 380..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 35
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 232
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17893096,
FT ECO:0000269|PubMed:19349973"
FT CARBOHYD 317
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 374
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 448
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 488
FT /note="L -> SVDEIELWTQYRV (in Ref. 1; CAA30332)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 488 AA; 54308 MW; 5B4E93D9012A2BE7 CRC64;
MTSNSCLISL GLLLVLIQIL APAKAAEHSV FTHKNASSVL GQLVTSSTLV WESYDPKDAT
QLQFAVEGGK YVTEDEHYPM YVCRVPIDGI QVSGHTEKIL QRHVCLAAHY KHGKYDNFDV
LMNKGHLGKV GWRHWRKFDA GVPVGAIRIG DDSYIGRHRA PSQPNKDGVV THWGADFNLG
HLEPVGLGKI RVIEAEREKY YDDGEVLVET EPFRYELRDI KLDRLRTDIQ ENMTELVTRK
LENLEDKYST VETILSYTFN YNQYWGSHEG VARGLPTKIF EKDEAVPAEI NWALKHTEKR
SENKAVHTKL WPGTAINVTL RGNYVTLEAP YSGKLFAFYY GSDESVSRKI SAEVRKSYLK
EVKLEFSPVY WIENGTLVPT TTTTTTTSTS TTTHATTTST NEPTPINEPP LVHMKDNGVQ
HSGPDTLEKT LHDSPSSNEL NSHEAPENMS SDPGKDVALA GFGVNAAGST FIAGSALLTL
LLTIFLSL
