ID   V073_ORFSA              Reviewed;         188 AA.
AC   Q6TVP7;
DT   20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 36.
DE   RecName: Full=Protein ORFV073;
OS   Orf virus (strain Goat/Texas/SA00/2000) (OV-SA00) (Orf virus-San Angelo
OS   2000).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Parapoxvirus.
OX   NCBI_TaxID=647330;
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14671098; DOI=10.1128/jvi.78.1.168-177.2004;
RA   Delhon G., Tulman E.R., Afonso C.L., Lu Z., de la Concha-Bermejillo A.,
RA   Lehmkuhl H.D., Piccone M.E., Kutish G.F., Rock D.L.;
RT   "Genomes of the parapoxviruses ORF virus and bovine papular stomatitis
RT   virus.";
RL   J. Virol. 78:168-177(2004).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH HOST IKBKG.
RX   PubMed=28787456; DOI=10.1371/journal.ppat.1006561;
RA   Khatiwada S., Delhon G., Nagendraprabhu P., Chaulagain S., Luo S.,
RA   Diel D.G., Flores E.F., Rock D.L.;
RT   "A parapoxviral virion protein inhibits NF-kappaB signaling early in
RT   infection.";
RL   PLoS Pathog. 13:E1006561-E1006561(2017).
CC   -!- FUNCTION: Plays a role in the inhibition of the host NF-kappa-B pathway
CC       early during infection. Prevents the host RELA subunit from reaching
CC       the nucleus and activate transcription. {ECO:0000269|PubMed:28787456}.
CC   -!- SUBUNIT: Interacts with host IKBKG; this interaction inhibits host NF-
CC       kappa-B pathway activation. {ECO:0000269|PubMed:28787456}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:28787456}. Host
CC       cytoplasm, host perinuclear region {ECO:0000269|PubMed:28787456}.
CC       Virion {ECO:0000269|PubMed:28787456}.
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DR   EMBL; AY386264; AAR98298.1; -; Genomic_DNA.
DR   RefSeq; NP_957850.1; NC_005336.1.
DR   SMR; Q6TVP7; -.
DR   GeneID; 2947673; -.
DR   KEGG; vg:2947673; -.
DR   Proteomes; UP000000870; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host nucleus; Host-virus interaction;
KW   Inhibition of host NF-kappa-B by virus; Reference proteome; Virion.
FT   CHAIN           1..188
FT                   /note="Protein ORFV073"
FT                   /id="PRO_0000442579"
SQ   SEQUENCE   188 AA;  22075 MW;  CD8BEA953F2A9C7B CRC64;
     MARRARFSPR LHIPAARAAL GPHLHFPRRR LVLRHCGVRA FVGDAIVSKK EMTNPLCAQA
     IVFGNGFVET YVRSLDPRLL GAYHALSRPV CERPLFAVRG WRRLFPIVAR RLDAVERRTR
     RVLRSMCRTY TTCMSADRAA AVSHPVMRRR WFGHRATKTR RARLRRRCRN RSSKRRAERR
     KRFCNYCP