V111_FOWPN
ID V111_FOWPN Reviewed; 444 AA.
AC Q9J5B1;
DT 29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Probable serine/threonine-protein kinase FPV111;
DE EC=2.7.11.1;
GN OrderedLocusNames=FPV111;
OS Fowlpox virus (strain NVSL) (FPV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Avipoxvirus.
OX NCBI_TaxID=928301;
OH NCBI_TaxID=7742; Vertebrata.
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10729156; DOI=10.1128/jvi.74.8.3815-3831.2000;
RA Afonso C.L., Tulman E.R., Lu Z., Zsak L., Kutish G.F., Rock D.L.;
RT "The genome of fowlpox virus.";
RL J. Virol. 74:3815-3831(2000).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. Poxviruses subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00159}.
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DR EMBL; AF198100; AAF44455.1; -; Genomic_DNA.
DR RefSeq; NP_039074.1; NC_002188.1.
DR GeneID; 1486659; -.
DR KEGG; vg:1486659; -.
DR Proteomes; UP000008597; Genome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR008790; Poxvirus_ser/thr_kinase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF05445; Pox_ser-thr_kin; 1.
DR PIRSF; PIRSF015695; STPK_F10L; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding; Kinase; Nucleotide-binding; Reference proteome;
KW Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..444
FT /note="Probable serine/threonine-protein kinase FPV111"
FT /id="PRO_0000086786"
FT DOMAIN 87..444
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT ACT_SITE 307
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 93..101
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 118
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 444 AA; 52848 MW; F8490899B8615971 CRC64;
MEFPDIHAYN STKYLEDGDT TILGDTIQFQ FIYENIDNKE HISLPKIKIF KYFRDKISFE
TLDRIIKNDY INPSYFQLKD KKFCAHNRDF YHLSTGGYGI IFRMEKYVVK FVFEDGSKKY
KPMEVTSEFT IPRFLYNNLK GDERKFIVCA IAMGINFKID FLRTIYYNTM SLMSALFNIM
EGEPLENKYS HRKVLRYFAK YKQSNDFVKL ISQFYPYVVN SNINVINNFN YLINFFERSR
RSNGYFNRGN IIIFPLAKCS AEKITPDNYA QYGFSSIVEY TKFMFLQIAL LYIKIYELPC
SNFVHLDLKP DNILIFDSKE PINIYVGDMH YVFKEPIRCT LNDFDFSQIS EIIPNKKAVT
AINKEQNWYY DFHFFSHVLF KVYPEISKDE DFTSLLNEFT ICDKYICENF RLQVNKLPSI
SFLINIVSRD IFSKWIDGKS TSHQ
