V15A1_AEDAE
ID V15A1_AEDAE Reviewed; 108 AA.
AC Q16KE2; O02541; Q26290;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Vitelline membrane protein 15a-1 {ECO:0000303|PubMed:9887508};
DE Flags: Precursor;
GN Name=15a-1 {ECO:0000312|EMBL:AAB25306.1}; ORFNames=AAEL013027;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAB25306.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=8432405; DOI=10.1006/dbio.1993.1052;
RA Lin Y., Hamblin M.T., Edwards M.J., Barillas-Mury C., Kanost M.R.,
RA Knipple D.C., Wolfner M.F., Hagedorn H.H.;
RT "Structure, expression, and hormonal control of genes from the mosquito,
RT Aedes aegypti, which encode proteins similar to the vitelline membrane
RT proteins of Drosophila melanogaster.";
RL Dev. Biol. 155:558-568(1993).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAB51282.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC STRAIN=Rockefeller {ECO:0000312|EMBL:AAB51282.1};
RX PubMed=9887508; DOI=10.1016/s0965-1748(98)00083-6;
RA Edwards M.J., Severson D.W., Hagedorn H.H.;
RT "Vitelline envelope genes of the yellow fever mosquito, Aedes aegypti.";
RL Insect Biochem. Mol. Biol. 28:915-925(1998).
RN [3] {ECO:0000312|EMBL:EAT34764.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P19425}.
CC -!- TISSUE SPECIFICITY: Expressed in the middle and posterior regions of
CC the follicle cells. {ECO:0000269|PubMed:9887508}.
CC -!- DEVELOPMENTAL STAGE: Synthesized and released from follicular
CC epithelium 18-24 hours after a blood meal. {ECO:0000269|PubMed:8432405,
CC ECO:0000269|PubMed:9887508}.
CC -!- SIMILARITY: Belongs to the vitelline membrane family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAT34764.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; S54555; AAB25306.1; -; mRNA.
DR EMBL; U91680; AAB51282.1; -; Genomic_DNA.
DR EMBL; CH477963; EAT34764.1; ALT_INIT; Genomic_DNA.
DR PIR; A48831; A48831.
DR RefSeq; XP_001663218.1; XM_001663168.1.
DR AlphaFoldDB; Q16KE2; -.
DR STRING; 7159.AAEL013027-PA; -.
DR GeneID; 5577129; -.
DR KEGG; aag:5577129; -.
DR VEuPathDB; VectorBase:AAEL013027; -.
DR eggNOG; ENOG502T8X3; Eukaryota.
DR HOGENOM; CLU_144558_0_0_1; -.
DR InParanoid; Q16KE2; -.
DR Proteomes; UP000008820; Chromosome 2.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; ISS:UniProtKB.
DR GO; GO:0048599; P:oocyte development; ISS:UniProtKB.
PE 2: Evidence at transcript level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..108
FT /note="Vitelline membrane protein 15a-1"
FT /evidence="ECO:0000255"
FT /id="PRO_0000399502"
FT DOMAIN 52..88
FT /note="VM"
FT REGION 87..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 108 AA; 11384 MW; 5AA28C43B2B1FF0F CRC64;
MNKFIILAIF ALAVGAMADY PKPAYHAPPP PPPHHLHAHP APAPVVHTYP VHAPHAKCGA
NLLVGCAPSV AHVPCVPLPG HAPAHGYGHA PAPHYRAPES DSFDQFEE
