ID   V15A3_AEDAE             Reviewed;         122 AA.
AC   Q16G12; A2I881; O01362;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 2.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Vitelline membrane protein 15a-3 {ECO:0000303|PubMed:9887508};
DE   Flags: Precursor;
GN   Name=15a-3 {ECO:0000312|EMBL:AAB51284.1}; ORFNames=AAEL014561;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAB51284.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RC   STRAIN=Rockefeller {ECO:0000312|EMBL:AAB51284.1};
RX   PubMed=9887508; DOI=10.1016/s0965-1748(98)00083-6;
RA   Edwards M.J., Severson D.W., Hagedorn H.H.;
RT   "Vitelline envelope genes of the yellow fever mosquito, Aedes aegypti.";
RL   Insect Biochem. Mol. Biol. 28:915-925(1998).
RN   [2] {ECO:0000312|EMBL:ABM68608.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=17519023; DOI=10.1186/gb-2007-8-5-r88;
RA   Lobo N.F., Campbell K.S., Thaner D., Debruyn B., Koo H., Gelbart W.M.,
RA   Loftus B.J., Severson D.W., Collins F.H.;
RT   "Analysis of 14 BAC sequences from the Aedes aegypti genome: a benchmark
RT   for genome annotation and assembly.";
RL   Genome Biol. 8:R88.1-R88.12(2007).
RN   [3] {ECO:0000312|EMBL:EAT33176.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P19425}.
CC   -!- TISSUE SPECIFICITY: Expressed in the middle and posterior regions of
CC       the follicle cells. {ECO:0000269|PubMed:9887508}.
CC   -!- DEVELOPMENTAL STAGE: Synthesized and released from follicular
CC       epithelium 18-24 hours after a blood meal.
CC       {ECO:0000269|PubMed:9887508}.
CC   -!- SIMILARITY: Belongs to the vitelline membrane protein family.
CC       {ECO:0000255}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAT33176.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; U91682; AAB51284.1; -; Genomic_DNA.
DR   EMBL; EF173374; ABM68608.1; -; Genomic_DNA.
DR   EMBL; CH478349; EAT33176.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_001649022.1; XM_001648972.1.
DR   AlphaFoldDB; Q16G12; -.
DR   STRING; 7159.AAEL014561-PA; -.
DR   GeneID; 5564677; -.
DR   KEGG; aag:5564677; -.
DR   VEuPathDB; VectorBase:AAEL014561; -.
DR   eggNOG; ENOG502T8X3; Eukaryota.
DR   HOGENOM; CLU_144558_0_0_1; -.
DR   InParanoid; Q16G12; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..122
FT                   /note="Vitelline membrane protein 15a-3"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000399503"
FT   DOMAIN          69..109
FT                   /note="VM"
FT   REGION          21..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          103..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..54
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        4
FT                   /note="F -> L (in Ref. 1; AAB51284)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        95
FT                   /note="L -> V (in Ref. 1; AAB51284)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   122 AA;  12859 MW;  7259927C8E6D706D CRC64;
     MNKFIILALF AVAAASAMPN YPPPPPKPYH APPPPPHHAH PPPPPPPPAH YGHHAHPAPA
     PVVHTYPVHA PHAKCGANLL VGCAPSVAHA PCVPLHGHGH GYPAPAPHYR APESDSFDQF
     EE