ID   V1A11_MOUSE             Reviewed;         318 AA.
AC   Q8R2E6;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Vomeronasal type-1 receptor A11;
GN   Name=V1ra11 {ECO:0000312|EMBL:AAL47869.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000312|EMBL:AAL47869.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11802169; DOI=10.1038/nn795;
RA   Rodriguez I., Del Punta K., Rothman A., Ishii T., Mombaerts P.;
RT   "Multiple new and isolated families within the mouse superfamily of V1r
RT   vomeronasal receptors.";
RL   Nat. Neurosci. 5:134-140(2002).
RN   [2] {ECO:0000305}
RP   PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=12214233; DOI=10.1038/nature00955;
RA   Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J.,
RA   Ogawa S., Zufall F., Mombaerts P.;
RT   "Deficient pheromone responses in mice lacking a cluster of vomeronasal
RT   receptor genes.";
RL   Nature 419:70-74(2002).
CC   -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC       social and reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene (12%
CC       of the V1r repertoire) show a lack of chemosensory response to a subset
CC       of known pheromonal ligands and changes in maternal aggression as well
CC       as male reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AY065464; AAL47869.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8R2E6; -.
DR   SMR; Q8R2E6; -.
DR   GlyGen; Q8R2E6; 1 site.
DR   PRIDE; Q8R2E6; -.
DR   InParanoid; Q8R2E6; -.
DR   PhylomeDB; Q8R2E6; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q8R2E6; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR   GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR   GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:UniProt.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR004072; Vmron_rcpt_1.
DR   PANTHER; PTHR24062; PTHR24062; 1.
DR   Pfam; PF03402; V1R; 1.
DR   PRINTS; PR01534; VOMERONASL1R.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..318
FT                   /note="Vomeronasal type-1 receptor A11"
FT                   /id="PRO_0000239967"
FT   TOPO_DOM        1..32
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        54..65
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        87..101
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..147
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        169..206
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..227
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        228..254
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        276..285
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..306
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        307..318
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        175
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        101..188
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   318 AA;  36003 MW;  E05BD84C3E0B305C CRC64;
     MSEILFFSPQ PLFSHMMNKN SRLHTHSNIK NTFFSEIGIG ISGNSFLLLF HILKFIRGHR
     PRLTDLPIGL LSLIHLLMLL LMAFIATDIF ISRRGWDGII CKFLVYLYGV LRGLSLCTTS
     MLSVLQAIIL SPRSSCLAKL KHKSPHHISC AIIFLSVLYM LISSHILLSI TATPNLTMND
     FLYVSQSCSL LPLSYLVQSM YSTLLALREV FLISLMVLST LYMVVLLCRH RKQAQHLQGT
     SLSPKASAEQ RATQTILMLM TFFVLMSIFD SIVSCSRTMF LDDPTSYSIH IFVMHIYATV
     SPFVFMSTEK HIVNILRG