V1AR_HUMAN
ID V1AR_HUMAN Reviewed; 418 AA.
AC P37288;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 190.
DE RecName: Full=Vasopressin V1a receptor;
DE Short=V1aR;
DE AltName: Full=AVPR V1a;
DE AltName: Full=Antidiuretic hormone receptor 1a;
DE AltName: Full=Vascular/hepatic-type arginine vasopressin receptor;
GN Name=AVPR1A; Synonyms=AVPR1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=8106369; DOI=10.1016/s0021-9258(17)41863-1;
RA Thibonnier M., Auzan C., Madhun Z., Wilkins P., Berti-Mattera L.,
RA Clauser E.;
RT "Molecular cloning, sequencing, and functional expression of a cDNA
RT encoding the human V1a vasopressin receptor.";
RL J. Biol. Chem. 269:3304-3310(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=8074728; DOI=10.1006/bbrc.1994.2150;
RA Hirasawa A., Shibata K., Kotosai K., Tsujimoto G.;
RT "Cloning, functional expression and tissue distribution of human cDNA for
RT the vascular-type vasopressin receptor.";
RL Biochem. Biophys. Res. Commun. 203:72-79(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lung;
RX PubMed=9357056; DOI=10.1016/s0196-9781(97)00072-7;
RA North W.G., Fay M.J., Longo K.A., Du J.;
RT "Functional vasopressin V1 type receptors are present in variant as well as
RT classical forms of small-cell carcinoma.";
RL Peptides 18:985-993(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9581826;
RA North W.G., Fay M.J., Longo K.A., Du J.;
RT "Expression of all known vasopressin receptor subtypes by small cell tumors
RT implies a multifaceted role for this neuropeptide.";
RL Cancer Res. 58:1866-1871(1998).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RA Kopatz S.A., Aronstam R.S., Sharma S.V.;
RT "cDNA clones of human proteins involved in signal transduction sequenced by
RT the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP ROLE IN SOCIAL BEHAVIOR.
RX PubMed=12082568; DOI=10.1038/sj.mp.4001125;
RA Kim S.J., Young L.J., Gonen D., Veenstra-VanderWeele J., Courchesne R.,
RA Courchesne E., Lord C., Leventhal B.L., Cook E.H. Jr., Insel T.R.;
RT "Transmission disequilibrium testing of arginine vasopressin receptor 1A
RT (AVPR1A) polymorphisms in autism.";
RL Mol. Psychiatry 7:503-507(2002).
RN [8]
RP X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 362-418.
RX PubMed=16511036; DOI=10.1107/s1744309105007293;
RA Adikesavan N.V., Mahmood S.S., Stanley N., Xu Z., Wu N., Thibonnier M.,
RA Shoham M.;
RT "A C-terminal segment of the V1R vasopressin receptor is unstructured in
RT the crystal structure of its chimera with the maltose-binding protein.";
RL Acta Crystallogr. F 61:341-345(2005).
CC -!- FUNCTION: Receptor for arginine vasopressin. The activity of this
CC receptor is mediated by G proteins which activate a phosphatidyl-
CC inositol-calcium second messenger system. Has been involved in social
CC behaviors, including affiliation and attachment.
CC {ECO:0000269|PubMed:12082568}.
CC -!- INTERACTION:
CC P37288; P25106: ACKR3; NbExp=7; IntAct=EBI-6656842, EBI-1965291;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: Differences in regional receptor expression in the brain
CC as well as differences in social behavior may result from a highly
CC variable repetitive sequence in the 5' flanking region of AVPR1A. One
CC such allelic variant has been linked to autism.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L25615; AAA62271.1; -; mRNA.
DR EMBL; U19906; AAB19232.1; -; Genomic_DNA.
DR EMBL; S73899; AAC60638.1; -; mRNA.
DR EMBL; AF030625; AAC51861.1; -; mRNA.
DR EMBL; AF101725; AAD17891.1; -; mRNA.
DR EMBL; AY322550; AAP84363.1; -; mRNA.
DR EMBL; BC074803; AAH74803.1; -; mRNA.
DR EMBL; BC074804; AAH74804.1; -; mRNA.
DR CCDS; CCDS8965.1; -.
DR PIR; A53046; A53046.
DR RefSeq; NP_000697.1; NM_000706.4.
DR PDB; 1YTV; X-ray; 1.80 A; M/N=362-418.
DR PDBsum; 1YTV; -.
DR AlphaFoldDB; P37288; -.
DR SMR; P37288; -.
DR BioGRID; 107033; 3.
DR IntAct; P37288; 4.
DR STRING; 9606.ENSP00000299178; -.
DR BindingDB; P37288; -.
DR ChEMBL; CHEMBL1889; -.
DR DrugBank; DB09059; Atosiban.
DR DrugBank; DB00872; Conivaptan.
DR DrugBank; DB00035; Desmopressin.
DR DrugBank; DB00093; Felypressin.
DR DrugBank; DB14642; Lypressin.
DR DrugBank; DB05452; PH-284.
DR DrugBank; DB13929; Relcovaptan.
DR DrugBank; DB02638; Terlipressin.
DR DrugBank; DB06212; Tolvaptan.
DR DrugBank; DB00067; Vasopressin.
DR DrugCentral; P37288; -.
DR GuidetoPHARMACOLOGY; 366; -.
DR GlyGen; P37288; 2 sites.
DR iPTMnet; P37288; -.
DR PhosphoSitePlus; P37288; -.
DR BioMuta; AVPR1A; -.
DR DMDM; 586197; -.
DR MassIVE; P37288; -.
DR PaxDb; P37288; -.
DR PeptideAtlas; P37288; -.
DR PRIDE; P37288; -.
DR ProteomicsDB; 55276; -.
DR Antibodypedia; 29106; 298 antibodies from 35 providers.
DR DNASU; 552; -.
DR Ensembl; ENST00000299178.4; ENSP00000299178.3; ENSG00000166148.4.
DR GeneID; 552; -.
DR KEGG; hsa:552; -.
DR MANE-Select; ENST00000299178.4; ENSP00000299178.3; NM_000706.5; NP_000697.1.
DR CTD; 552; -.
DR DisGeNET; 552; -.
DR GeneCards; AVPR1A; -.
DR HGNC; HGNC:895; AVPR1A.
DR HPA; ENSG00000166148; Tissue enhanced (adrenal).
DR MIM; 600821; gene.
DR neXtProt; NX_P37288; -.
DR OpenTargets; ENSG00000166148; -.
DR PharmGKB; PA25187; -.
DR VEuPathDB; HostDB:ENSG00000166148; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244882; -.
DR HOGENOM; CLU_009579_15_3_1; -.
DR InParanoid; P37288; -.
DR OMA; RFRGPDW; -.
DR OrthoDB; 890925at2759; -.
DR PhylomeDB; P37288; -.
DR TreeFam; TF106499; -.
DR PathwayCommons; P37288; -.
DR Reactome; R-HSA-388479; Vasopressin-like receptors.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR Reactome; R-HSA-5619099; Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI).
DR SignaLink; P37288; -.
DR SIGNOR; P37288; -.
DR BioGRID-ORCS; 552; 51 hits in 1071 CRISPR screens.
DR ChiTaRS; AVPR1A; human.
DR EvolutionaryTrace; P37288; -.
DR GeneWiki; Arginine_vasopressin_receptor_1A; -.
DR GenomeRNAi; 552; -.
DR Pharos; P37288; Tclin.
DR PRO; PR:P37288; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; P37288; protein.
DR Bgee; ENSG00000166148; Expressed in left adrenal gland and 137 other tissues.
DR ExpressionAtlas; P37288; baseline and differential.
DR Genevisible; P37288; HS.
DR GO; GO:0030139; C:endocytic vesicle; IDA:ARUK-UCL.
DR GO; GO:0005768; C:endosome; IDA:ARUK-UCL.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:ARUK-UCL.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0017046; F:peptide hormone binding; IEA:Ensembl.
DR GO; GO:0005080; F:protein kinase C binding; TAS:ProtInc.
DR GO; GO:0031894; F:V1A vasopressin receptor binding; IEA:Ensembl.
DR GO; GO:0005000; F:vasopressin receptor activity; IDA:ARUK-UCL.
DR GO; GO:0007202; P:activation of phospholipase C activity; TAS:ProtInc.
DR GO; GO:0008015; P:blood circulation; TAS:ProtInc.
DR GO; GO:0019722; P:calcium-mediated signaling; IEA:Ensembl.
DR GO; GO:0042631; P:cellular response to water deprivation; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc.
DR GO; GO:0007625; P:grooming behavior; IEA:Ensembl.
DR GO; GO:0002125; P:maternal aggressive behavior; IEA:Ensembl.
DR GO; GO:0042711; P:maternal behavior; IEA:Ensembl.
DR GO; GO:0010259; P:multicellular organism aging; IEA:Ensembl.
DR GO; GO:0014902; P:myotube differentiation; IEA:Ensembl.
DR GO; GO:0007621; P:negative regulation of female receptivity; IEA:Ensembl.
DR GO; GO:0051970; P:negative regulation of transmission of nerve impulse; IEA:Ensembl.
DR GO; GO:0043084; P:penile erection; IEA:Ensembl.
DR GO; GO:0030307; P:positive regulation of cell growth; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:ARUK-UCL.
DR GO; GO:0032849; P:positive regulation of cellular pH reduction; IEA:Ensembl.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; TAS:ProtInc.
DR GO; GO:0014049; P:positive regulation of glutamate secretion; IEA:Ensembl.
DR GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR GO; GO:0031394; P:positive regulation of prostaglandin biosynthetic process; IEA:Ensembl.
DR GO; GO:0035815; P:positive regulation of renal sodium excretion; IEA:Ensembl.
DR GO; GO:0003084; P:positive regulation of systemic arterial blood pressure; IEA:Ensembl.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; IBA:GO_Central.
DR GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IBA:GO_Central.
DR GO; GO:0051412; P:response to corticosterone; IEA:Ensembl.
DR GO; GO:0035176; P:social behavior; IEA:Ensembl.
DR GO; GO:0042713; P:sperm ejaculation; IEA:Ensembl.
DR GO; GO:0021537; P:telencephalon development; IEA:Ensembl.
DR GO; GO:0150104; P:transport across blood-brain barrier; NAS:ARUK-UCL.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR015076; V1R_C.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR InterPro; IPR001224; Vprs_V1A_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF08983; DUF1856; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00896; VASOPRESSINR.
DR PRINTS; PR00752; VASOPRSNV1AR.
DR SMART; SM01164; DUF1856; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Disulfide bond; G-protein coupled receptor;
KW Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..418
FT /note="Vasopressin V1a receptor"
FT /id="PRO_0000070197"
FT TOPO_DOM 1..52
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..76
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..88
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..110
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..125
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..147
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..168
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..190
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 191..218
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 240..293
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..313
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 314..331
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..351
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 352..418
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 377..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 404
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q62463"
FT LIPID 365
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 366
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 196
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 124..203
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 6
FT /note="G -> S (in dbSNP:rs2228154)"
FT /id="VAR_022065"
SQ SEQUENCE 418 AA; 46800 MW; 477D4260EC826561 CRC64;
MRLSAGPDAG PSGNSSPWWP LATGAGNTSR EAEALGEGNG PPRDVRNEEL AKLEIAVLAV
TFAVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV AFFQVLPQMC WDITYRFRGP
DWLCRVVKHL QVFGMFASAY MLVVMTADRY IAVCHPLKTL QQPARRSRLM IAAAWVLSFV
LSTPQYFVFS MIEVNNVTKA RDCWATFIQP WGSRAYVTWM TGGIFVAPVV ILGTCYGFIC
YNIWCNVRGK TASRQSKGAE QAGVAFQKGF LLAPCVSSVK SISRAKIRTV KMTFVIVTAY
IVCWAPFFII QMWSVWDPMS VWTESENPTI TITALLGSLN SCCNPWIYMF FSGHLLQDCV
QSFPCCQNMK EKFNKEDTDS MSRRQTFYSN NRSPTNSTGM WKDSPKSSKS IKFIPVST
