V1AR_MICOH
ID V1AR_MICOH Reviewed; 420 AA.
AC Q9WTV9;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Vasopressin V1a receptor;
DE Short=V1aR;
DE AltName: Full=AVPR V1a;
DE AltName: Full=Antidiuretic hormone receptor 1a;
DE AltName: Full=Vascular/hepatic-type arginine vasopressin receptor;
GN Name=Avpr1a;
OS Microtus ochrogaster (Prairie vole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Arvicolinae; Microtus.
OX NCBI_TaxID=79684;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Brain;
RX PubMed=10466725; DOI=10.1038/23475;
RA Young L.J., Nilsen R., Waymire K.G., MacGregor G.R., Insel T.R.;
RT "Increased affiliative response to vasopressin in mice expressing the V1a
RT receptor from a monogamous vole.";
RL Nature 400:766-768(1999).
RN [2]
RP ROLE IN SOCIAL BEHAVIOR.
RX PubMed=15201909; DOI=10.1038/nature02539;
RA Lim M.M., Wang Z., Olazabal D.E., Ren X., Terwilliger E.F., Young L.J.;
RT "Enhanced partner preference in a promiscuous species by manipulating the
RT expression of a single gene.";
RL Nature 429:754-757(2004).
CC -!- FUNCTION: Receptor for arginine vasopressin. The activity of this
CC receptor is mediated by G proteins which activate a phosphatidyl-
CC inositol-calcium second messenger system. Involved in social memory
CC formation. {ECO:0000269|PubMed:15201909}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: In prairie and pine voles, the 5' regulatory region of
CC AVPR1A contains a microsatellite region that is virtually absent from
CC montane and meadow voles. This species-specific microsatellite
CC polymorphism modulates gene expression in a cell-type-dependent manner
CC and generates a great individual variability in the brain expression
CC pattern. This polymorphism is correlated with monogamous social
CC organization.
CC -!- MISCELLANEOUS: Prairie voles exhibit a monogamous social structure in
CC nature, whereas closely related meadow voles are solitary and
CC polygamous. AVPR1A is expressed at higher levels in the ventral
CC forebrain of monogamous than in promiscuous vole species, whereas
CC dopamine receptor distribution is relatively conserved between species.
CC The partner preference formation in the socially promiscuous meadow
CC vole is increased by AVPR1A gene transfer into the ventral forebrain.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=Nature's philanderers
CC - Issue 52 of November 2004;
CC URL="https://web.expasy.org/spotlight/back_issues/052";
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DR EMBL; AF069304; AAD02821.2; -; Genomic_DNA.
DR AlphaFoldDB; Q9WTV9; -.
DR SMR; Q9WTV9; -.
DR BindingDB; Q9WTV9; -.
DR ChEMBL; CHEMBL2016428; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005000; F:vasopressin receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR015076; V1R_C.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR InterPro; IPR001224; Vprs_V1A_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF08983; DUF1856; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00896; VASOPRESSINR.
DR PRINTS; PR00752; VASOPRSNV1AR.
DR SMART; SM01164; DUF1856; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Phosphoprotein; Receptor; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..420
FT /note="Vasopressin V1a receptor"
FT /id="PRO_0000070199"
FT TOPO_DOM 1..54
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..92
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..125
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..168
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..225
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247..294
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..331
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..352
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 353..420
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 406
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q62463"
FT LIPID 367
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 368
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 198
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 124..205
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 420 AA; 47560 MW; 8055B79C351E3DFE CRC64;
MSFPRGSYDP AASNSSPWWP LSAEDANSSW EAAGHQKGSD PSGDVRNEEL AKLEIAVLAV
IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV AFFQVLPQLC WDITYRFRGP
DWLCRVVKHL QVFAMFASAY MLVVMTADRY IAVCHPLKTL QQPTRRSRLM IAASWVLSFL
LSTPQYFIFS MIEIEVNNGT KTQDCWATFI QPWGTRAYVT WMTSGVFVVP VVILGTCYGF
ICYHIWRNVR GKTASRQSKG SGEDVAPFHK GLLVTPCVSS VKTISRAKIR TVKMTFVIVT
AYILCWAPFF IVQMWSVWDD NFIWTDSENP SITITALLAS LNSCCNPWIY MFFSGHLLQD
CVQSFPCCQR MVQKFTKDDS DNMSRRHTSY SNNRSPTNST GTWKDSPKSS RSIRFIPVST
