V1AR_MOUSE
ID V1AR_MOUSE Reviewed; 423 AA.
AC Q62463; Q62464; Q9QYH2;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 172.
DE RecName: Full=Vasopressin V1a receptor;
DE Short=V1aR;
DE AltName: Full=AVPR V1a;
DE AltName: Full=Antidiuretic hormone receptor 1a;
DE AltName: Full=Vascular/hepatic-type arginine vasopressin receptor;
GN Name=Avpr1a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RA Onodera Y., Maekawa K., Arai Y.;
RL Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RX PubMed=10669045; DOI=10.1254/jjp.81.388;
RA Kikuchi S., Tanoue A., Goda N., Matsuo N., Tsujimoto G.;
RT "Structure and sequence of the mouse V1a and V1b vasopressin receptor
RT genes.";
RL Jpn. J. Pharmacol. 81:388-392(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP ROLE IN SOCIAL BEHAVIOR.
RX PubMed=14647484; DOI=10.1038/sj.npp.1300360;
RA Bielsky I.F., Hu S.B., Szegda K.L., Westphal H., Young L.J.;
RT "Profound impairment in social recognition and reduction in anxiety-like
RT behavior in vasopressin V1a receptor knockout mice.";
RL Neuropsychopharmacology 29:483-493(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Receptor for arginine vasopressin. The activity of this
CC receptor is mediated by G proteins which activate a phosphatidyl-
CC inositol-calcium second messenger system. Involved in social memory
CC formation. {ECO:0000269|PubMed:14647484}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: Knockout mice display deficits in individual
CC discrimination. Male mice lacking functional AVPR1A (V1aRKO) exhibit
CC markedly reduced anxiety-like behavior and a profound impairment in
CC social recognition. V1aRKO performed normally on spatial and non-social
CC olfactory learning and memory tasks.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00521}.
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DR EMBL; D49729; BAA08566.1; -; mRNA.
DR EMBL; D49730; BAA08567.1; -; mRNA.
DR EMBL; AB030013; BAA89050.1; -; Genomic_DNA.
DR EMBL; BC024149; AAH24149.1; -; mRNA.
DR CCDS; CCDS24215.1; -.
DR RefSeq; NP_058543.2; NM_016847.2.
DR AlphaFoldDB; Q62463; -.
DR SMR; Q62463; -.
DR STRING; 10090.ENSMUSP00000020323; -.
DR BindingDB; Q62463; -.
DR ChEMBL; CHEMBL3414410; -.
DR GlyGen; Q62463; 2 sites.
DR iPTMnet; Q62463; -.
DR PhosphoSitePlus; Q62463; -.
DR PaxDb; Q62463; -.
DR PRIDE; Q62463; -.
DR ProteomicsDB; 298261; -.
DR Antibodypedia; 29106; 298 antibodies from 35 providers.
DR DNASU; 54140; -.
DR Ensembl; ENSMUST00000020323; ENSMUSP00000020323; ENSMUSG00000020123.
DR GeneID; 54140; -.
DR KEGG; mmu:54140; -.
DR UCSC; uc007hge.1; mouse.
DR CTD; 552; -.
DR MGI; MGI:1859216; Avpr1a.
DR VEuPathDB; HostDB:ENSMUSG00000020123; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244882; -.
DR HOGENOM; CLU_009579_15_3_1; -.
DR InParanoid; Q62463; -.
DR OMA; RFRGPDW; -.
DR OrthoDB; 890925at2759; -.
DR PhylomeDB; Q62463; -.
DR TreeFam; TF106499; -.
DR Reactome; R-MMU-388479; Vasopressin-like receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR BioGRID-ORCS; 54140; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q62463; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q62463; protein.
DR Bgee; ENSMUSG00000020123; Expressed in liver and 110 other tissues.
DR ExpressionAtlas; Q62463; baseline and differential.
DR Genevisible; Q62463; MM.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISO:MGI.
DR GO; GO:0030139; C:endocytic vesicle; ISO:MGI.
DR GO; GO:0005768; C:endosome; ISO:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0017046; F:peptide hormone binding; ISO:MGI.
DR GO; GO:0031894; F:V1A vasopressin receptor binding; ISO:MGI.
DR GO; GO:0005000; F:vasopressin receptor activity; ISO:MGI.
DR GO; GO:0019722; P:calcium-mediated signaling; ISO:MGI.
DR GO; GO:0042631; P:cellular response to water deprivation; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007625; P:grooming behavior; ISO:MGI.
DR GO; GO:0002125; P:maternal aggressive behavior; ISO:MGI.
DR GO; GO:0042711; P:maternal behavior; ISO:MGI.
DR GO; GO:0010259; P:multicellular organism aging; IMP:MGI.
DR GO; GO:0014902; P:myotube differentiation; IEA:Ensembl.
DR GO; GO:0007621; P:negative regulation of female receptivity; ISO:MGI.
DR GO; GO:0051970; P:negative regulation of transmission of nerve impulse; ISO:MGI.
DR GO; GO:0043084; P:penile erection; ISO:MGI.
DR GO; GO:0045777; P:positive regulation of blood pressure; ISO:MGI.
DR GO; GO:0030307; P:positive regulation of cell growth; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0032849; P:positive regulation of cellular pH reduction; ISO:MGI.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR GO; GO:0014049; P:positive regulation of glutamate secretion; ISO:MGI.
DR GO; GO:0010460; P:positive regulation of heart rate; ISO:MGI.
DR GO; GO:0031394; P:positive regulation of prostaglandin biosynthetic process; ISO:MGI.
DR GO; GO:0035815; P:positive regulation of renal sodium excretion; ISO:MGI.
DR GO; GO:0003084; P:positive regulation of systemic arterial blood pressure; ISO:MGI.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; ISO:MGI.
DR GO; GO:0008217; P:regulation of blood pressure; IMP:MGI.
DR GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IGI:MGI.
DR GO; GO:0051412; P:response to corticosterone; IEA:Ensembl.
DR GO; GO:0010035; P:response to inorganic substance; ISO:MGI.
DR GO; GO:0010033; P:response to organic substance; ISO:MGI.
DR GO; GO:0035176; P:social behavior; ISO:MGI.
DR GO; GO:0042713; P:sperm ejaculation; ISO:MGI.
DR GO; GO:0021537; P:telencephalon development; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR015076; V1R_C.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR InterPro; IPR001224; Vprs_V1A_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF08983; DUF1856; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00896; VASOPRESSINR.
DR PRINTS; PR00752; VASOPRSNV1AR.
DR SMART; SM01164; DUF1856; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Phosphoprotein; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..423
FT /note="Vasopressin V1a receptor"
FT /id="PRO_0000070200"
FT TOPO_DOM 1..52
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..76
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..88
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..110
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..125
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..147
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..168
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..190
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 191..220
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 242..298
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..318
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 319..336
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..356
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 357..423
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 409
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT LIPID 370
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 371
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 198
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 124..205
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 41..42
FT /note="PP -> RR"
FT VARIANT 55
FT /note="V -> F"
SQ SEQUENCE 423 AA; 47182 MW; C75AFF1D0A082CC6 CRC64;
MSFPRGSHDL PAGNSSPWWP LTTEGANSSR EAAGLGEGGS PPGDVRNEEL AKLEVTVLAV
IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV AFFQVLPQLC WDITYRFRGP
DWLCRVVKHL QVFAMFASSY MLVVMTADRY IAVCHPLKTL QQPARRSRLM IAASWGLSFV
LSIPQYFIFS VIEFEVNNGT KAQDCWATFI PPWGTRAYVT WMTSGVFVVP VIILGTCYGF
ICYHIWRNVR GKTASRQSKG GKGSGEAAGP FHKGLLVTPC VSSVKSISRA KIRTVKMTFV
IVSAYILCWT PFFIVQMWSV WDTNFVWTDS ENPSTTITAL LASLNSCCNP WIYMFFSGHL
LQDCVQSFPC CQSIAQKFAK DDSDSMSRRQ TSYSNNRSPT NSTGTWKDSP KSSKSIRFIP
VST
