V1AR_SHEEP
ID V1AR_SHEEP Reviewed; 418 AA.
AC P48043;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Vasopressin V1a receptor;
DE Short=V1aR;
DE AltName: Full=AVPR V1a;
DE AltName: Full=Antidiuretic hormone receptor 1a;
DE AltName: Full=Vascular/hepatic-type arginine vasopressin receptor;
GN Name=AVPR1A;
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7548217; DOI=10.1016/0167-4781(95)00125-z;
RA Hutchins A.-M., Phillips P.A., Venter D.J., Burrell L.M., Johnston C.I.;
RT "Molecular cloning and sequencing of the gene encoding a sheep arginine
RT vasopressin type 1a receptor.";
RL Biochim. Biophys. Acta 1263:266-270(1995).
CC -!- FUNCTION: Receptor for arginine vasopressin. The activity of this
CC receptor is mediated by G proteins which activate a phosphatidyl-
CC inositol-calcium second messenger system.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC41627.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; L41502; AAC41628.1; -; Genomic_DNA.
DR EMBL; L41502; AAC41627.1; ALT_INIT; Genomic_DNA.
DR PIR; S59601; S59601.
DR AlphaFoldDB; P48043; -.
DR SMR; P48043; -.
DR STRING; 9940.ENSOARP00000004394; -.
DR eggNOG; KOG3656; Eukaryota.
DR Proteomes; UP000002356; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005000; F:vasopressin receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR015076; V1R_C.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR InterPro; IPR001224; Vprs_V1A_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF08983; DUF1856; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00896; VASOPRESSINR.
DR PRINTS; PR00752; VASOPRSNV1AR.
DR SMART; SM01164; DUF1856; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Phosphoprotein; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..418
FT /note="Vasopressin V1a receptor"
FT /id="PRO_0000070202"
FT TOPO_DOM 1..51
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..75
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..87
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..109
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..124
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..146
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..167
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..189
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..217
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 239..293
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..313
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 314..331
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..351
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 352..418
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 377..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 404
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q62463"
FT LIPID 365
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 366
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 13
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 26
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 195
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 319
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 123..202
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 418 AA; 46521 MW; BDE60C985A6215CE CRC64;
MRFSGSPSPG PSNSSRWWPL DAGDANTSGD LAGLGEDGGP QADTRNEELA KLEIAVLAVI
FVVAVLGNSS VLLALHRTPR KTSRMHLFIR HLSLADLAVA FFQVLPQLGW DITYRFRGPD
GLCRVVKHMQ VFAMFASAYM LVVMTADRYI AVCHPLKTLQ QPARRSRLMI AAAWVLSFVL
STPQYFVFSM VEVSNVTKTY DCWANFIHPW GLPAYVTWMT GSVFVAPVVI LGTCYGFICY
HIWRKVRGKT AGRQGGPAEG AGESALYRGV LHARCVSSVK TISRAKIRTV KMTFVIVTAY
IVCWAPFFII QMWSAWDKNF SWVESENPAT AIPALLASLN SCCNPWIYMF FSGHLLQDCA
QSFPCCQNVK RTFTREGSDS MSRRQTSFTN NRSPTNSMGT WKDSPKSSKS IKFIPVST
