V1BR_MOUSE
ID V1BR_MOUSE Reviewed; 421 AA.
AC Q9WU02;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Vasopressin V1b receptor;
DE Short=V1bR;
DE AltName: Full=AVPR V1b;
DE AltName: Full=AVPR V3;
DE AltName: Full=Antidiuretic hormone receptor 1b;
DE AltName: Full=Vasopressin V3 receptor;
GN Name=Avpr1b; Synonyms=V1br;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv;
RX PubMed=10343284; DOI=10.1677/jme.0.0220251;
RA Ventura M.A., Rene P., de Keyzer Y., Bertagna X., Clauser E.;
RT "Gene and cDNA cloning and characterization of the mouse V3/V1b pituitary
RT vasopressin receptor.";
RL J. Mol. Endocrinol. 22:251-260(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RX PubMed=10669045; DOI=10.1254/jjp.81.388;
RA Kikuchi S., Tanoue A., Goda N., Matsuo N., Tsujimoto G.;
RT "Structure and sequence of the mouse V1a and V1b vasopressin receptor
RT genes.";
RL Jpn. J. Pharmacol. 81:388-392(1999).
CC -!- FUNCTION: Receptor for arginine vasopressin. The activity of this
CC receptor is mediated by G proteins which activate a phosphatidyl-
CC inositol-calcium second messenger system.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00521}.
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DR EMBL; AF098867; AAD27957.1; -; Genomic_DNA.
DR EMBL; AF098866; AAD27957.1; JOINED; Genomic_DNA.
DR EMBL; AB030449; BAA89205.1; -; Genomic_DNA.
DR CCDS; CCDS35703.1; -.
DR RefSeq; NP_036054.1; NM_011924.2.
DR AlphaFoldDB; Q9WU02; -.
DR SMR; Q9WU02; -.
DR BioGRID; 204921; 1.
DR STRING; 10090.ENSMUSP00000027690; -.
DR GlyGen; Q9WU02; 1 site.
DR PhosphoSitePlus; Q9WU02; -.
DR PaxDb; Q9WU02; -.
DR PRIDE; Q9WU02; -.
DR ProteomicsDB; 300100; -.
DR Antibodypedia; 20687; 389 antibodies from 36 providers.
DR DNASU; 26361; -.
DR Ensembl; ENSMUST00000027690; ENSMUSP00000027690; ENSMUSG00000026432.
DR GeneID; 26361; -.
DR KEGG; mmu:26361; -.
DR UCSC; uc007cnl.1; mouse.
DR CTD; 553; -.
DR MGI; MGI:1347010; Avpr1b.
DR VEuPathDB; HostDB:ENSMUSG00000026432; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244882; -.
DR HOGENOM; CLU_009579_15_3_1; -.
DR InParanoid; Q9WU02; -.
DR OMA; FNSHLWP; -.
DR OrthoDB; 890925at2759; -.
DR PhylomeDB; Q9WU02; -.
DR TreeFam; TF106499; -.
DR Reactome; R-MMU-388479; Vasopressin-like receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR BioGRID-ORCS; 26361; 4 hits in 76 CRISPR screens.
DR PRO; PR:Q9WU02; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9WU02; protein.
DR Bgee; ENSMUSG00000026432; Expressed in embryonic post-anal tail and 22 other tissues.
DR ExpressionAtlas; Q9WU02; baseline and differential.
DR Genevisible; Q9WU02; MM.
DR GO; GO:0043679; C:axon terminus; IEA:Ensembl.
DR GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043204; C:perikaryon; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0017046; F:peptide hormone binding; IEA:Ensembl.
DR GO; GO:0005000; F:vasopressin receptor activity; ISO:MGI.
DR GO; GO:0007202; P:activation of phospholipase C activity; ISO:MGI.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:MGI.
DR GO; GO:0042538; P:hyperosmotic salinity response; IEA:Ensembl.
DR GO; GO:0010259; P:multicellular organism aging; IMP:MGI.
DR GO; GO:0090238; P:positive regulation of arachidonic acid secretion; ISO:MGI.
DR GO; GO:0032849; P:positive regulation of cellular pH reduction; IEA:Ensembl.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR GO; GO:0014049; P:positive regulation of glutamate secretion; IEA:Ensembl.
DR GO; GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; ISO:MGI.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:MGI.
DR GO; GO:0032430; P:positive regulation of phospholipase A2 activity; ISO:MGI.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; IBA:GO_Central.
DR GO; GO:0008217; P:regulation of blood pressure; IMP:MGI.
DR GO; GO:0042127; P:regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IGI:MGI.
DR GO; GO:0046718; P:viral entry into host cell; ISO:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR015076; V1R_C.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR InterPro; IPR000628; Vprs_rcpt_V1B.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF08983; DUF1856; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00896; VASOPRESSINR.
DR PRINTS; PR00897; VASOPRSNV1BR.
DR SMART; SM01164; DUF1856; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..421
FT /note="Vasopressin V1b receptor"
FT /id="PRO_0000070204"
FT TOPO_DOM 1..35
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..59
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..71
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..108
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..173
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 174..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..280
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..300
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 301..318
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..338
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 339..421
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 399..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 107..186
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 421 AA; 46539 MW; E867DC0C700F596F CRC64;
MDSEPSWTAT PSPGGTLFVP NTTTPWLGRD EELAKVEIGI LATVLVLATG GNLAVLLILG
LQGHKRSRMH LFVLHLALTD LGVALFQVLP QLLWDITYRF QGSDLLCRAV KYLQVLSMFA
STYMLLAMTL DRYLAVCHPL RSLQQPSQST YPLIAAPWLL AAILSLPQVF IFSLREVIQG
SGVLDCWADF YFSWGPRAYI TWTTMAIFVL PVVVLTACYG LICHEIYKNL KVKTQAGREE
RRGWPKSSSS AAAAATRGLP SRVSSISTIS RAKIRTVKMT FVIVLAYIAC WAPFFSVQMW
SVWDENAPNE DSTNVAFTIS MLLGNLSSCC NPWIYMGFNS HLLPRSLSHR ACCRGSKPRV
HRQLSNSSLA SRRTTLLTHT CGPSTLRLSL NLSLHAKPKP AGSLKDLEQV DGEATMETSI
S
