V1BR_RAT
ID V1BR_RAT Reviewed; 425 AA.
AC P48974;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 25-MAY-2022, entry version 133.
DE RecName: Full=Vasopressin V1b receptor;
DE Short=V1bR;
DE AltName: Full=AVPR V1b;
DE AltName: Full=AVPR V3;
DE AltName: Full=Antidiuretic hormone receptor 1b;
DE AltName: Full=Vasopressin V3 receptor;
GN Name=Avpr1b;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar; TISSUE=Pituitary;
RX PubMed=7626108; DOI=10.1006/bbrc.1995.2033;
RA Saito M., Sugimoto T., Tahara A., Kawashima H.;
RT "Molecular cloning and characterization of rat V1b vasopressin receptor:
RT evidence for its expression in extra-pituitary tissues.";
RL Biochem. Biophys. Res. Commun. 212:751-757(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Pituitary;
RX PubMed=7624319; DOI=10.1073/pnas.92.15.6783;
RA Lolait S.J., O'Carroll A.-M., Mahan L.C., Felder C.C., Button D.C.,
RA Young W.S. III, Mezey E., Brownstein M.J.;
RT "Extrapituitary expression of the rat V1b vasopressin receptor gene.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:6783-6787(1995).
CC -!- FUNCTION: Receptor for arginine vasopressin. The activity of this
CC receptor is mediated by G proteins which activate a phosphatidyl-
CC inositol-calcium second messenger system.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00521}.
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DR EMBL; D45400; BAA08242.1; -; mRNA.
DR EMBL; U27322; AAC52235.1; -; mRNA.
DR PIR; JC4179; JC4179.
DR AlphaFoldDB; P48974; -.
DR SMR; P48974; -.
DR STRING; 10116.ENSRNOP00000064689; -.
DR BindingDB; P48974; -.
DR ChEMBL; CHEMBL2659; -.
DR DrugCentral; P48974; -.
DR GuidetoPHARMACOLOGY; 367; -.
DR CarbonylDB; P48974; -.
DR GlyGen; P48974; 1 site.
DR PhosphoSitePlus; P48974; -.
DR PaxDb; P48974; -.
DR PRIDE; P48974; -.
DR UCSC; RGD:61886; rat.
DR RGD; 61886; Avpr1b.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; P48974; -.
DR PhylomeDB; P48974; -.
DR PRO; PR:P48974; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0005000; F:vasopressin receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; IBA:GO_Central.
DR GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR015076; V1R_C.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR InterPro; IPR000628; Vprs_rcpt_V1B.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF08983; DUF1856; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00896; VASOPRESSINR.
DR PRINTS; PR00897; VASOPRSNV1BR.
DR SMART; SM01164; DUF1856; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..425
FT /note="Vasopressin V1b receptor"
FT /id="PRO_0000070205"
FT TOPO_DOM 1..35
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..59
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..71
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..108
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..173
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 174..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..284
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..304
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 305..322
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..342
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 343..425
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 107..186
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 66
FT /note="R -> P (in Ref. 2; AAC52235)"
FT /evidence="ECO:0000305"
FT CONFLICT 216
FT /note="S -> T (in Ref. 2; AAC52235)"
FT /evidence="ECO:0000305"
FT CONFLICT 255..258
FT /note="Missing (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 425 AA; 47086 MW; 87EE6B7A897305F8 CRC64;
MNSEPSWTAT PSPGGTLPVP NATTPWLGRD EELAKVEIGI LATVLVLATG GNLAVLLTLG
RHGHKRSRMH LFVLHLALTD LGVALFQVLP QLLWDITYRF QGSDLLCRAV KYLQVLSMFA
STYMLLAMTL DRYLAVCHPL RSLRQPSQST YPLIAAPWLL AAILSLPQVF IFSLREVIQG
SGVLDCWADF YFSWGPRAYI TWTTMAIFVL PVAVLSACYG LICHEIYKNL KVKTQAGREE
RRGWRTWDKS SSSAVATAAT RGLPSRVSSI STISRAKIRT VKMTFVIVLA YIACWAPFFS
VQMWSVWDEN APNEDSTNVA FTISMLLGNL SSCCNPWIYM GFNSRLLPRS LSHHACCTGS
KPQVHRQLST SSLTSRRTTL LTHACGSPTL RLSLNLSLRA KPRPAGSLKD LEQVDGEATM
ETSIF
