V1R40_MOUSE
ID V1R40_MOUSE Reviewed; 310 AA.
AC Q9EQ46;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Vomeronasal type-1 receptor 40;
DE AltName: Full=Vomeronasal type-1 receptor A11;
DE AltName: Full=Vomeronasal type-1 receptor B7;
GN Name=Vmn1r40; Synonyms=V1ra11 {ECO:0000312|EMBL:BAB79217.1}, V1rb7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAG42087.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ {ECO:0000312|EMBL:AAG42087.1};
RX PubMed=11116090; DOI=10.1101/gr.10.12.1958;
RA Del Punta K., Rothman A., Rodriguez I., Mombaerts P.;
RT "Sequence diversity and genomic organization of vomeronasal receptor genes
RT in the mouse.";
RL Genome Res. 10:1958-1967(2000).
RN [2] {ECO:0000312|EMBL:BAB79217.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Sam M., Matsunami H., Buck L.;
RT "Vomeronasal receptor gene diversity in the mammalian genome.";
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=12214233; DOI=10.1038/nature00955;
RA Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J.,
RA Ogawa S., Zufall F., Mombaerts P.;
RT "Deficient pheromone responses in mice lacking a cluster of vomeronasal
RT receptor genes.";
RL Nature 419:70-74(2002).
CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC social and reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene (12%
CC of the V1r repertoire) show a lack of chemosensory response to a subset
CC of known pheromonal ligands and changes in maternal aggression as well
CC as male reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF291493; AAG42087.1; -; Genomic_DNA.
DR EMBL; AB062900; BAB79217.1; -; Genomic_DNA.
DR CCDS; CCDS20346.1; -.
DR RefSeq; NP_444458.1; NM_053228.1.
DR RefSeq; XP_006505444.1; XM_006505381.3.
DR RefSeq; XP_006505445.1; XM_006505382.3.
DR AlphaFoldDB; Q9EQ46; -.
DR SMR; Q9EQ46; -.
DR STRING; 10090.ENSMUSP00000074655; -.
DR GlyGen; Q9EQ46; 1 site.
DR PhosphoSitePlus; Q9EQ46; -.
DR PaxDb; Q9EQ46; -.
DR PRIDE; Q9EQ46; -.
DR DNASU; 113855; -.
DR Ensembl; ENSMUST00000075158; ENSMUSP00000074655; ENSMUSG00000096051.
DR Ensembl; ENSMUST00000226925; ENSMUSP00000153836; ENSMUSG00000096051.
DR Ensembl; ENSMUST00000228642; ENSMUSP00000154581; ENSMUSG00000096051.
DR GeneID; 113855; -.
DR KEGG; mmu:113855; -.
DR UCSC; uc009cwk.1; mouse.
DR CTD; 113855; -.
DR MGI; MGI:2148518; Vmn1r40.
DR VEuPathDB; HostDB:ENSMUSG00000096051; -.
DR eggNOG; ENOG502SNRJ; Eukaryota.
DR GeneTree; ENSGT01030000234553; -.
DR HOGENOM; CLU_058641_0_0_1; -.
DR InParanoid; Q9EQ46; -.
DR OMA; MCKSAFY; -.
DR OrthoDB; 1390012at2759; -.
DR PhylomeDB; Q9EQ46; -.
DR BioGRID-ORCS; 113855; 2 hits in 67 CRISPR screens.
DR PRO; PR:Q9EQ46; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9EQ46; protein.
DR Bgee; ENSMUSG00000096051; Expressed in lumbar subsegment of spinal cord and 4 other tissues.
DR ExpressionAtlas; Q9EQ46; differential.
DR Genevisible; Q9EQ46; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:MGI.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Vomeronasal type-1 receptor 40"
FT /id="PRO_0000239979"
FT TOPO_DOM 1..20
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..41
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 42..50
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..190
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 85..172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 310 AA; 35207 MW; D60E8D958E961435 CRC64;
MNKANMLRTD KDMQIILFSE VSVGISANSI LFIAHVCMIL GENRPKPIDL YIAFLSLTQL
MLLITMGLIA VDMFLSQGIW DSTTCQSLIY LHRLLRGLSL CATCLLNILW TITLSSRSFC
STKFKHKSPH HISGAFIFFC VLYMSFSSHL FISIIATHNL TSENFIYVTQ SCSLLPLSYS
RTSMFSAPMA IREAFLVSLM ALSSGYMVAL LWRHKKQAQH LHSTSLSSKA SPEQRATRTI
LLLMSFFVVL YILENAVFYS RIKFKDGSIL YCVQIILCHS YATVNPFVFI CTEKHIIKFW
ESKCGRIVNI
