V1R41_MOUSE
ID V1R41_MOUSE Reviewed; 310 AA.
AC Q9EQ44; Q8VIC4;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Vomeronasal type-1 receptor 41;
DE AltName: Full=Vomeronasal type-1 receptor A12;
DE AltName: Full=Vomeronasal type-1 receptor B9;
GN Name=Vmn1r41; Synonyms=V1ra12 {ECO:0000312|EMBL:BAB79218.1}, V1rb9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAG42089.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ {ECO:0000312|EMBL:AAG42089.1};
RX PubMed=11116090; DOI=10.1101/gr.10.12.1958;
RA Del Punta K., Rothman A., Rodriguez I., Mombaerts P.;
RT "Sequence diversity and genomic organization of vomeronasal receptor genes
RT in the mouse.";
RL Genome Res. 10:1958-1967(2000).
RN [2] {ECO:0000312|EMBL:BAB79218.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Sam M., Matsunami H., Buck L.;
RT "Vomeronasal receptor gene diversity in the mammalian genome.";
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=12214233; DOI=10.1038/nature00955;
RA Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J.,
RA Ogawa S., Zufall F., Mombaerts P.;
RT "Deficient pheromone responses in mice lacking a cluster of vomeronasal
RT receptor genes.";
RL Nature 419:70-74(2002).
CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC social and reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene (12%
CC of the V1r repertoire) show a lack of chemosensory response to a subset
CC of known pheromonal ligands and changes in maternal aggression as well
CC as male reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB79218.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF291495; AAG42089.1; -; Genomic_DNA.
DR EMBL; AB062901; BAB79218.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_444460.2; NM_053230.2.
DR RefSeq; XP_017176825.1; XM_017321336.1.
DR AlphaFoldDB; Q9EQ44; -.
DR SMR; Q9EQ44; -.
DR BioGRID; 227525; 1.
DR STRING; 10090.ENSMUSP00000100705; -.
DR GlyGen; Q9EQ44; 1 site.
DR PaxDb; Q9EQ44; -.
DR PRIDE; Q9EQ44; -.
DR DNASU; 113857; -.
DR GeneID; 113857; -.
DR KEGG; mmu:113857; -.
DR UCSC; uc009cwl.3; mouse.
DR CTD; 113857; -.
DR MGI; MGI:2148520; Vmn1r41.
DR eggNOG; ENOG502SNRJ; Eukaryota.
DR InParanoid; Q9EQ44; -.
DR OMA; TRTIMIL; -.
DR OrthoDB; 1390012at2759; -.
DR PhylomeDB; Q9EQ44; -.
DR BioGRID-ORCS; 113857; 1 hit in 66 CRISPR screens.
DR PRO; PR:Q9EQ44; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q9EQ44; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:MGI.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Vomeronasal type-1 receptor 41"
FT /id="PRO_0000239981"
FT TOPO_DOM 1..20
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..41
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 42..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..190
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 85..172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 310 AA; 35228 MW; 19D8ED1740455DAE CRC64;
MNKANLLYTD TNMKTFLFSE VSVGISANSM LFIVHICILL GENRPKPINL YIAFLSLTQL
MLLITMGLIV ADMFMSQGIW DSITCQSLIY LHRLLRGLTL CATCLLNVLW TITLSPRSSC
LTKFKHKSPH HISGAFLFFC ALYMSFSSHL FLSIIATPNL TSEDFMYVTQ SCSLLSMSYS
RTSMFSTAIA IREAFLISLF ALCSGYMVAL LWRHKKQAWD LHSTNVSSKS SPEQRATRTI
MLLMSFFVVL YVLENAVFHS RMKFKDGSML YCVQIIVSHS YATVSPFVLI CTEKRMIKFW
GSMFGRIVNI
